دورية أكاديمية
A comparative study of 0.125% racemic bupivacaine (S50-R50) and 0.125% and 0.25% 50% enantiomeric excess bupivacaine (S75-R25) in epidural anesthesia for labor analgesia.
| العنوان: | A comparative study of 0.125% racemic bupivacaine (S50-R50) and 0.125% and 0.25% 50% enantiomeric excess bupivacaine (S75-R25) in epidural anesthesia for labor analgesia. |
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| المؤلفون: | Duarte NM; Instituto Materno Infantil Professor Fernando Figueira (IMIP), Recife, PE. nadia.duarte@terra.com.br, Caetano AM, Lima LC, das Chagas AS |
| المصدر: | Revista brasileira de anestesiologia [Rev Bras Anestesiol] 2008 Jan-Feb; Vol. 58 (1), pp. 5-14. |
| نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial |
| اللغة: | English; Portuguese |
| بيانات الدورية: | Publisher: Elsevier Editora Ltda. em nome de Sociedade Brasileira de Anestesiologia Country of Publication: Brazil NLM ID: 0401316 Publication Model: Print Cited Medium: Print ISSN: 0034-7094 (Print) Linking ISSN: 00347094 NLM ISO Abbreviation: Rev Bras Anestesiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Rio de Janeiro, Brazil] : Elsevier Editora Ltda. em nome de Sociedade Brasileira de Anestesiologia Original Publication: Rio de Janeiro : Sociedade Brasileira de Anestesiologia |
| مواضيع طبية MeSH: | Analgesia, Obstetrical* , Anesthesia, Epidural*, Anesthetics, Local/*administration & dosage , Bupivacaine/*administration & dosage, Double-Blind Method ; Female ; Humans ; Pregnancy ; Young Adult |
| مستخلص: | Background and Objectives: Continuous epidural block is used for relief of labor pain and it is associated with a low incidence of complications. Studies with the levorotatory isomer of local anesthetics demonstrated that they are safer regarding the cardiotoxicity. The objective of this study was to compare analgesia and motor blockade of 0.125% bupivacaine (S50-R50) and 0.125% and 0.25% 50% enantiomeric excess bupivacaine (S75-R25) in continuous epidural block for labor analgesia. Methods: Seventy-five patients in labor participated in this randomized, double-blind study after signing an informed consent. Patients were divided in three groups: GI - 0.125% bupivacaine (S50-R50); GII - 0.125% bupivacaine (S75-R25) and GIII - 0.25% bupivacaine (S75-R25). Results: The latency of analgesia, levels of sensorial blockade, volume of local anesthetic, duration of labor and analgesia, frequency of instrumental delivery, Apgar scores, or pH of umbilical cord blood showed no statistically significant differences. The length of time until the first rescue dose was greater and pain scores at 45 minutes were also greater in the 0.25% bupivacaine (S75-R25) group. The intensity of the motor blockade was greater in the 0.125% bupivacaine (S50-R50) group. Conclusions: The motor blockade was less intense with bupivacaine (S75-R25) regardless the concentration, resulting in analgesia of better quality without interfering with the evolution of labor or the vitality of newborns. |
| التعليقات: | Comment in: Rev Bras Anestesiol. 2008 Sep-Oct;58(5):553; author reply 553-4, 552-3. (PMID: 19382414) |
| المشرفين على المادة: | 0 (Anesthetics, Local) Y8335394RO (Bupivacaine) |
| تواريخ الأحداث: | Date Created: 20090422 Date Completed: 20090603 Latest Revision: 20191111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s0034-70942008000100002 |
| PMID: | 19378539 |
| قاعدة البيانات: | MEDLINE |
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