دورية أكاديمية
أعرض في EDS

Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.

التفاصيل البيبلوغرافية
العنوان: Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.
المؤلفون: Feodorova VA; Russian State Anti-Plague Research Institute 'Microbe,' 46, Universitetskaya Street, Saratov, 410005, Russia. feodorova@san.ru, Pan'kina LN, Savostina EP, Kuznetsov OS, Konnov NP, Sayapina LV, Dentovskaya SV, Shaikhutdinova RZ, Ageev SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP, Motin VL
المصدر: Vaccine [Vaccine] 2009 Apr 06; Vol. 27 (16), pp. 2240-50. Date of Electronic Publication: 2009 Feb 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0264-410X (Print) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam, The Netherlands : Elsevier Science
Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983-
مواضيع طبية MeSH: Antigens, Bacterial/*biosynthesis , Plague Vaccine/*immunology , Yersinia pestis/*immunology, Animals ; Epitopes ; Female ; Immunization ; Lipid A/genetics ; Lipopolysaccharides/biosynthesis ; Mice ; Mutation ; Tumor Necrosis Factor-alpha/biosynthesis ; Vaccines, Attenuated/immunology ; Virulence/genetics ; Yersinia pestis/genetics ; Yersinia pestis/pathogenicity
مستخلص: Deletion mutants in the lpxM gene in two Yersinia pestis strains, the live Russian vaccine strain EV NIIEG and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (LPS). Analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivity of numerous major proteins and carbohydrate antigens, including F1, Pla, Ymt, V antigen, LPS, and ECA. Moreover, both mutants demonstrated altered epitope specificities of the antigens as determined in immunodot-ELISAs and immunoblotting analyses using a panel of monoclonal antibodies. The strains also differed in their susceptibility to the diagnostic plague bacteriophage L-413C. These findings indicate that the effects of the lpxM mutation on reduced virulence and enhanced immunity of the Y. pestis EV DeltalpxM is also associated with these pleiotropic changes and not just to changes in the lipid A acylation.
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معلومات مُعتمدة: U54 AI057156 United States AI NIAID NIH HHS; AI46706-06 United States AI NIAID NIH HHS; R21 AI046706 United States AI NIAID NIH HHS; 1-U54-AI-057156 United States AI NIAID NIH HHS; R01 AI046706 United States AI NIAID NIH HHS; R01 AI046706-10 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Antigens, Bacterial)
0 (Epitopes)
0 (Lipid A)
0 (Lipopolysaccharides)
0 (Plague Vaccine)
0 (Tumor Necrosis Factor-alpha)
0 (Vaccines, Attenuated)
تواريخ الأحداث: Date Created: 20090512 Date Completed: 20090618 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC2999740
DOI: 10.1016/j.vaccine.2009.02.020
PMID: 19428838
قاعدة البيانات: MEDLINE
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