دورية أكاديمية
Heterosubtypic T-cell responses against avian influenza H5 haemagglutinin are frequently detected in individuals vaccinated against or previously infected with human subtypes of influenza.
| العنوان: | Heterosubtypic T-cell responses against avian influenza H5 haemagglutinin are frequently detected in individuals vaccinated against or previously infected with human subtypes of influenza. |
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| المؤلفون: | Goy K; Burnet Institute, Prahran, Vic, Australia., Von Bibra S, Lewis J, Laurie K, Barr I, Anderson D, Hellard M, Ffrench R |
| المصدر: | Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2008 Jul; Vol. 2 (4), pp. 115-25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 101304007 Publication Model: Print Cited Medium: Internet ISSN: 1750-2659 (Electronic) Linking ISSN: 17502640 NLM ISO Abbreviation: Influenza Other Respir Viruses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Wiley, c2007- |
| مواضيع طبية MeSH: | Antigens, Viral/*immunology , Hemagglutinin Glycoproteins, Influenza Virus/*immunology , Influenza Vaccines/*immunology , Influenza, Human/*immunology , T-Lymphocytes/*immunology, Adult ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza A Virus, H5N1 Subtype/immunology ; Interferon-gamma/metabolism ; Interleukin-2/metabolism ; Male ; Middle Aged ; Young Adult |
| مستخلص: | Background: Cellula r immune responses play a critical role in providing help for the production of neutralizing antibodies to influenza virus, as well as producing anti-viral cytokines and killing infected cells in the lung. Heterosubtypic T-cell responses between different subtypes of influenza have been shown to exist in humans and to provide protection against morbidity and mortality associated with H5N1 infection in animal challenge models. Therefore, existing T-cell responses induced by natural infection or vaccination in humans may provide some degree of protection from infection with H5N1 strains, or may attenuate the severity of disease. Objectives: To investigate heterosubtypic T-cell responses to avian influenza in humans. Methods: T-cell responses to an overlapping set of H5 HA peptides and inactivated viruses (H1N1, H3N2 and H5N1) were assessed using IFN-gamma and IL-2 enzyme-linked immunospot (ELISpot) assays in a cohort of adults either vaccinated against seasonal influenza in the last 3 years (n = 20) or previously infected (n = 40). Results: T-cell responses to all three subtypes of virus were found in both infected and vaccinated individuals by IFN-gamma and IL-2 ELISpot assays. Approximately half of the participants from each group had a positive T-cell response to the H5 HA peptides in the IFN-gamma or IL-2 ELISpot assay. Conclusions: Heterosubtypic T-cell responses to H5 HA occur quite frequently in vaccinated and infected individuals. Further investigation of these responses and what role they may play upon challenge or vaccination against H5N1 may assist in vaccine design for avian influenza. |
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| المشرفين على المادة: | 0 (Antigens, Viral) 0 (Hemagglutinin Glycoproteins, Influenza Virus) 0 (Influenza Vaccines) 0 (Interleukin-2) 0 (hemagglutinin, avian influenza A virus) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20090521 Date Completed: 20090609 Latest Revision: 20211020 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4634225 |
| DOI: | 10.1111/j.1750-2659.2008.00046.x |
| PMID: | 19453462 |
| قاعدة البيانات: | MEDLINE |
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