دورية أكاديمية
Extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae bacteremia. Risk factors and outcome in the eastern region of Saudi Arabia.
| العنوان: | Extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae bacteremia. Risk factors and outcome in the eastern region of Saudi Arabia. |
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| المؤلفون: | Memon JI; Department of Medicine, King Abdulaziz National Guard Hospital, Al-Ahsa, Kingdom of Saudi Arabia. memonj@ngha.med.sa, Rehmani RS, Ahmed MU, Elgendy AM, Nizami IY |
| المصدر: | Saudi medical journal [Saudi Med J] 2009 Jun; Vol. 30 (6), pp. 803-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Country of Publication: Saudi Arabia NLM ID: 7909441 Publication Model: Print Cited Medium: Internet ISSN: 1658-3175 (Electronic) Linking ISSN: 03795284 NLM ISO Abbreviation: Saudi Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Riyadh : Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Original Publication: Riyadh, Saudi Arabia, Riyadh Al-Kharj Hospital Programme. |
| مواضيع طبية MeSH: | Bacteremia/*enzymology , Escherichia coli/*enzymology , Klebsiella pneumoniae/*enzymology , beta-Lactamases/*biosynthesis, Adult ; Aged ; Aged, 80 and over ; Bacteremia/mortality ; Case-Control Studies ; Female ; Humans ; Male ; Risk Factors ; Saudi Arabia |
| مستخلص: | Objective: To study the risk factors for bacteremia caused by Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) producing extended-spectrum beta-lactamase (ESBL) and their outcome. Methods: A case-control study was conducted in King Abdul-Aziz National Guard Hospital, Al-Ahsa, Kingdom of Saudi Arabia from January 2006 through December 2007. All adult patients for whom culture results were positive for E. coli or K. pneumoniae were eligible. Twenty-nine patients with ESBL producing bacteremia (cases) were compared with 80 patients with non-ESBL producing bacteremia controls. Hospital mortality was the primary end point. Univariable and multivariable logistic regression were performed to analyze risk factors for ESBL bacteremia and its 30-day mortality. Results: A total of 109 patients with bacteremia were enrolled that included 29 cases and 80 controls. Forty-nine percent of the patients were male. The mean age was 60.2+/-21.1 years. Nosocomial infection was the only independent risk factor for bacteremia due to ESBL-producing pathogens (odds ratio [OR] 3.40, 95% confidence interval [CI] 1.14-8.44, p=0.02). Overall 30-day mortality was 22%, and was similar in both groups. The nosocomial infection (OR 3.20, 95% CI 1.48-6.94, p=0.01), presentation with septic shock (OR 48.88, 95% CI 6.01-397.32, p=0.004), and intensive care unit care (OR 7.40, 95% CI 1.94 -28.34, p=0.001) were the independent risk factors for 30-day mortality. Conclusion: The ESBL rate is high in our study among the bacteremic patients. Nosocomial infection is identified both as a risk factor for ESBL bacteremia and mortality. |
| التعليقات: | Comment in: Saudi Med J. 2009 Oct;30(10):1366-7; author reply1366-7. (PMID: 19838454) |
| المشرفين على المادة: | EC 3.5.2.6 (beta-Lactamases) |
| تواريخ الأحداث: | Date Created: 20090616 Date Completed: 20090831 Latest Revision: 20091021 |
| رمز التحديث: | 20231215 |
| PMID: | 19526164 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1658-3175 |
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