دورية أكاديمية
The prognostic role of classical and nonclassical MHC class I expression in endometrial cancer.
| العنوان: | The prognostic role of classical and nonclassical MHC class I expression in endometrial cancer. |
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| المؤلفون: | Bijen CB; Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Bantema-Joppe EJ, de Jong RA, Leffers N, Mourits MJ, Eggink HF, van der Zee AG, Hollema H, de Bock GH, Nijman HW |
| المصدر: | International journal of cancer [Int J Cancer] 2010 Mar 15; Vol. 126 (6), pp. 1417-27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| مواضيع طبية MeSH: | Endometrial Neoplasms/*metabolism , Endometrial Neoplasms/*pathology , HLA Antigens/*biosynthesis , Histocompatibility Antigens Class I/*biosynthesis, Aged ; Analysis of Variance ; Disease-Free Survival ; Female ; HLA-A Antigens/biosynthesis ; HLA-B Antigens/biosynthesis ; HLA-C Antigens/biosynthesis ; HLA-G Antigens ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasm Staging ; Prognosis ; Tissue Array Analysis ; beta 2-Microglobulin/biosynthesis |
| مستخلص: | The aim of this study was to investigate classical MHC class I and nonclassical MHC (human leukocyte antigen-G [HLA-G]) expression in a large cohort of patients with endometrial cancer, to determine the prognostic value of these cell surface markers and their relation with clinicopathological variables. Tissue microarrays containing epithelial endometrial carcinoma tissue from 554 patients were stained for classical and nonclassical MHC class I using the following monoclonal antibodies: 4H84 (anti-HLA-G), beta2-m (anti-beta-2-microglobulin) and HC-10 (MHC class I antigen heavy chain). Expression data were linked to known clinicopathological characteristics and survival. HLA-G upregulation and MHC class I downregulation in neoplastic cells was observed in 40% and 48%, respectively. Nonendometrioid tumor type, advanced stage disease (FIGO stage > or = II) and poorly or undifferentiated tumors were associated with MHC class I downregulation. Absence of HLA-G expression was independently associated with MHC class I downregulation. In univariate analysis, MHC class I downregulation was a predictor of worse disease-specific survival. Prognostic unfavorable tumor characteristics were correlated with downregulation of MHC class I expression in endometrial cancer cells. Furthermore, downregulated MHC class I has a negative impact on disease-specific survival, observed in a large cohort of patients with endometrial cancer. As there seems to be a relation between classical and nonclassical MHC class I molecules (HLA-G), further research is warranted to unravel this regulatory mechanism. |
| المشرفين على المادة: | 0 (HLA Antigens) 0 (HLA-A Antigens) 0 (HLA-B Antigens) 0 (HLA-C Antigens) 0 (HLA-G Antigens) 0 (Histocompatibility Antigens Class I) 0 (beta 2-Microglobulin) |
| تواريخ الأحداث: | Date Created: 20090904 Date Completed: 20100225 Latest Revision: 20210103 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ijc.24852 |
| PMID: | 19728333 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0215 |
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| DOI: | 10.1002/ijc.24852 |