دورية أكاديمية
Effect of blood pressure lowering on markers of kidney disease progression.
| العنوان: | Effect of blood pressure lowering on markers of kidney disease progression. |
|---|---|
| المؤلفون: | Udani SM; Section of Nephrology, University of Chicago, Chicago, IL 60637, USA., Koyner JL |
| المصدر: | Current hypertension reports [Curr Hypertens Rep] 2009 Oct; Vol. 11 (5), pp. 368-74. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Current Science, Inc Country of Publication: United States NLM ID: 100888982 Publication Model: Print Cited Medium: Internet ISSN: 1534-3111 (Electronic) Linking ISSN: 15226417 NLM ISO Abbreviation: Curr Hypertens Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Current Science, Inc., c1999- |
| مواضيع طبية MeSH: | Antihypertensive Agents/*therapeutic use , Blood Pressure/*drug effects , Hypertension/*complications , Kidney Failure, Chronic/*physiopathology, Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Biomarkers ; Calcium Channel Blockers/therapeutic use ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Kidney Failure, Chronic/drug therapy ; Kidney Failure, Chronic/prevention & control |
| مستخلص: | Hypertension remains a common comorbidity and cause of chronic kidney disease (CKD). As the number of patients with CKD grows, so does the need to identify modifiable risk factors for CKD progression. Data on slowing progression of CKD or preventing end-stage renal disease with aggressive blood pressure control have not yielded definitive conclusions regarding ideal blood pressure targets. Shifting the focus of antihypertensive therapy to alternative markers of end-organ damage, specifically proteinuria, has yielded some promise in preventing the progression of CKD. Nevertheless, proteinuria and decline in estimated GFR may represent an irreversible degree of injury to the kidney that limits the impact of any therapy. The identification and use of novel markers of kidney injury to assess the impact of antihyper-tensive therapy may yield clearer direction with regard to optimal management of hypertension in the setting of CKD. |
| Number of References: | 25 |
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| معلومات مُعتمدة: | K23 DK081616-01A1 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Angiotensin II Type 1 Receptor Blockers) 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Antihypertensive Agents) 0 (Biomarkers) 0 (Calcium Channel Blockers) |
| تواريخ الأحداث: | Date Created: 20090910 Date Completed: 20100929 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s11906-009-0061-2 |
| PMID: | 19737454 |
| قاعدة البيانات: | MEDLINE |
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