دورية أكاديمية
أعرض في EDS

Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity.

التفاصيل البيبلوغرافية
العنوان: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity.
المؤلفون: Shaarawy SM; Department of Cancer Biology, National Research Institute, Cairo University, Cairo, Egypt., Tohamy AA, Elgendy SM, Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Matrougui K
المصدر: International journal of biological sciences [Int J Biol Sci] 2009 Aug 11; Vol. 5 (6), pp. 549-57. Date of Electronic Publication: 2009 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: Electronic Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lake Haven, N.S.W., Australia : Ivyspring International, c2004-
مواضيع طبية MeSH: Carbon Tetrachloride/*toxicity , Diethylnitrosamine/*toxicity , Garlic/*chemistry , Liver/*drug effects , Liver/*metabolism , Plant Extracts/*pharmacology , Silymarin/*pharmacology , Solvents/*toxicity, Animals ; Apoptosis/drug effects ; Flow Cytometry ; Glutathione/metabolism ; Glutathione Reductase/metabolism ; Glutathione Transferase/metabolism ; Immunohistochemistry ; Liver/enzymology ; Male ; Microtubule-Associated Proteins/metabolism ; Oxidative Stress/drug effects ; Rats ; Silymarin/administration & dosage ; Superoxide Dismutase/metabolism ; Survivin
مستخلص: Background: The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4))-induced hepatotoxicity in male albino rats.
Methods and Results: Animals were pretreated with garlic, silymarin or both for one week prior to the injection of NDEA. Then animals received a single injection of NDEA followed by weekly subcutaneous injections of CCl(4) for 6 weeks. Oral administration was then continued along with the injection of CCl(4) for the duration of the experiment. Serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-S-transferase (GST) and glutathione reductase (GSR) were measured. Injection of NDEA induced a significant elevation in serum AST, ALT and ALP. In the liver, NDEA increased oxidative stress through the increase in LPO and decrease in SOD, and GSH-dependent enzymes. Although administration of garlic or silymarin significantly reduced the liver toxicity, combined administration was more effective in preventing the development of hepatotoxicity.
Conclusion: These novel findings suggest that silymarin and garlic have a synergistic effect, and could be used as hepatoprotective agents against hepatotoxicity.
References: Free Radic Biol Med. 1989;7(6):637-44. (PMID: 2695407)
J Natl Cancer Inst. 1989 Jan 18;81(2):162-4. (PMID: 2909758)
Enzyme. 1971;12(5):561-73. (PMID: 5169852)
Cancer Detect Prev. 1999;23(6):534-8. (PMID: 10571664)
Chem Biol Interact. 2005 Oct 20;156(2-3):101-11. (PMID: 16144695)
Nutr Cancer. 1997;28(2):184-8. (PMID: 9290126)
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66. (PMID: 17237035)
Arch Biochem Biophys. 1959 May;82(1):70-7. (PMID: 13650640)
Life Sci. 2001 Jan 12;68(8):921-31. (PMID: 11213362)
Nat Rev Cancer. 2006 Sep;6(9):674-87. (PMID: 16929323)
Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:138P-141P. (PMID: 9503421)
Mutat Res. 1985 Jul;143(3):127-9. (PMID: 4010692)
Ecotoxicol Environ Saf. 1985 Feb;9(1):64-70. (PMID: 3987592)
Methods Mol Biol. 2004;279:1-8. (PMID: 15199232)
Biochem Biophys Res Commun. 1972 Jan 31;46(2):849-54. (PMID: 4400444)
Nutrition. 2005 Apr;21(4):530-6. (PMID: 15811776)
Phytother Res. 2000 Nov;14(7):564-7. (PMID: 11054854)
Chem Biol Interact. 2006 Jun 10;161(2):104-14. (PMID: 16643877)
World J Gastroenterol. 2004 May 1;10(9):1268-75. (PMID: 15112340)
Carcinogenesis. 1993 Aug;14(8):1627-31. (PMID: 8353846)
Pol J Pharmacol. 2003 Jan-Feb;55(1):37-42. (PMID: 12856824)
Sci Am. 1985 Mar;252(3):114-9. (PMID: 3975593)
Int J Pharm. 2006 Aug 17;319(1-2):121-9. (PMID: 16837151)
Clin Chim Acta. 2004 Dec;350(1-2):65-72. (PMID: 15530461)
Life Sci. 2005 Apr 15;76(22):2593-606. (PMID: 15769483)
J Natl Cancer Inst. 2002 Nov 6;94(21):1648-51. (PMID: 12419792)
Eur J Pharmacol. 2007 Apr 10;560(2-3):110-6. (PMID: 17300777)
Planta Med. 1992 Oct;58(5):468-9. (PMID: 1470670)
Int J Cancer. 1995 Jul 28;62(3):237-44. (PMID: 7628866)
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):29-41. (PMID: 16170386)
Carcinogenesis. 1996 Mar;17(3):477-84. (PMID: 8631133)
J Nutr. 1999 Mar;129(3):657-61. (PMID: 10082770)
Crit Rev Food Sci Nutr. 2004;44(7-8):575-86. (PMID: 15969329)
Carbohydr Res. 2003 Jul 22;338(15):1603-7. (PMID: 12860431)
Free Radic Biol Med. 1999 Jan;26(1-2):202-26. (PMID: 9890655)
Carcinogenesis. 1992 Oct;13(10):1847-51. (PMID: 1423843)
Arch Biochem Biophys. 1979 Nov;198(1):241-6. (PMID: 507842)
Environ Health Perspect. 2001 Sep;109(9):943-7. (PMID: 11673124)
Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):414-9. (PMID: 17516996)
Mol Carcinog. 2005 Sep;44(1):11-20. (PMID: 15924350)
Life Sci. 2003 Sep 26;73(19):2515-26. (PMID: 12954459)
Cell Biochem Funct. 2000 Mar;18(1):17-21. (PMID: 10686579)
Br Med Bull. 1993 Jul;49(3):679-99. (PMID: 8221032)
J Biol Chem. 1974 Nov 25;249(22):7130-9. (PMID: 4436300)
Dig Dis Sci. 2005 Oct;50(10):1807-12. (PMID: 16187178)
Methods Enzymol. 1990;186:407-21. (PMID: 2233308)
J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713)
Liver Int. 2007 Apr;27(3):393-9. (PMID: 17355462)
Am J Clin Pathol. 1957 Jul;28(1):56-63. (PMID: 13458125)
Cancer Surv. 1989;8(2):241-50. (PMID: 2696579)
فهرسة مساهمة: Keywords: Garlic; Hepatotoxicity; NDEA; Silymarin; liver enzymes; oxidative stress; rats.
المشرفين على المادة: 0 (Birc5 protein, rat)
0 (Microtubule-Associated Proteins)
0 (Plant Extracts)
0 (Silymarin)
0 (Solvents)
0 (Survivin)
3IQ78TTX1A (Diethylnitrosamine)
CL2T97X0V0 (Carbon Tetrachloride)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.8.1.7 (Glutathione Reductase)
EC 2.5.1.18 (Glutathione Transferase)
GAN16C9B8O (Glutathione)
تواريخ الأحداث: Date Created: 20090911 Date Completed: 20091027 Latest Revision: 20211020
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC2737715
DOI: 10.7150/ijbs.5.549
PMID: 19742242
قاعدة البيانات: MEDLINE
الوصف
تدمد:1449-2288
DOI:10.7150/ijbs.5.549