دورية أكاديمية
HER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma.
| العنوان: | HER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma. |
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| المؤلفون: | Tse GM; Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. garytse@cuhk.edu.hk, Yu KH, Chan AW, King AD, Chen GG, Wong KT, Tsang RK, Chan AB |
| المصدر: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2009 Oct; Vol. 141 (4), pp. 467-73. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Oxford] : Wiley Original Publication: [Rochester, Minn.] : The Academy, [c1981- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*analysis , Carcinoma, Squamous Cell/*mortality , Head and Neck Neoplasms/*mortality , Receptor, ErbB-2/*analysis, Carcinoma, Squamous Cell/chemistry ; Carcinoma, Squamous Cell/pathology ; Female ; Head and Neck Neoplasms/chemistry ; Head and Neck Neoplasms/pathology ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neck ; Prognosis ; Survival Analysis ; Survival Rate ; Trans-Activators/analysis ; Transcription Factors ; Tumor Suppressor Proteins/analysis |
| مستخلص: | Objective: To investigate the prognostic value of HER2 and p63 expression in head and neck squamous cell carcinoma (HNSCC). Study Design: A case review of 186 HNSCCs from the oral tongue, palate, maxillary sinus, floor of mouth, oropharynx, hypopharynx, and larynx. Subjects and Methods: All primary tumor specimens were evaluated by immunohistochemistry for HER2 and p63 expressions, which were correlated with clinical parameters including age, sex, grade, lymph node metastases, stage, and survival. Results: One hundred forty-one patients had stage III-IV disease and 109 had lymph node metastases. For all cases, T and N stages were significant prognostic predictors for both overall and disease-free survivals. In the node-positive subgroup, T stage and HER2 expression were significant prognostic predictors for both overall and disease-free survivals. Conclusion: HER2 may be associated with longer survival in node-positive patients with HNSCC. |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (TP63 protein, human) 0 (Trans-Activators) 0 (Transcription Factors) 0 (Tumor Suppressor Proteins) EC 2.7.10.1 (Receptor, ErbB-2) |
| تواريخ الأحداث: | Date Created: 20090930 Date Completed: 20091201 Latest Revision: 20211130 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.otohns.2009.06.747 |
| PMID: | 19786214 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-6817 |
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| DOI: | 10.1016/j.otohns.2009.06.747 |