دورية أكاديمية
أعرض في EDS

Efficacy and side effects of diclofenac patch in treatment of patients with myofascial pain syndrome of the upper trapezius.

التفاصيل البيبلوغرافية
العنوان: Efficacy and side effects of diclofenac patch in treatment of patients with myofascial pain syndrome of the upper trapezius.
المؤلفون: Hsieh LF; Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. M001026@ms.skh.org.tw, Hong CZ, Chern SH, Chen CC
المصدر: Journal of pain and symptom management [J Pain Symptom Manage] 2010 Jan; Vol. 39 (1), pp. 116-25. Date of Electronic Publication: 2009 Oct 12.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8605836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6513 (Electronic) Linking ISSN: 08853924 NLM ISO Abbreviation: J Pain Symptom Manage Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: [Madison, WI : Dept. of Anesthesiology, University of Wisconsin--Madison, 1986-
مواضيع طبية MeSH: Diclofenac/*administration & dosage , Diclofenac/*adverse effects , Muscle, Skeletal/*physiopathology , Myofascial Pain Syndromes/*drug therapy, Administration, Cutaneous ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Chi-Square Distribution ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Myofascial Pain Syndromes/physiopathology ; Severity of Illness Index ; Treatment Outcome
مستخلص: Locally administered nonsteroidal anti-inflammatory drugs have been widely used in acute soft-tissue damage and articular musculoskeletal pain. This double-blind, placebo-controlled, randomized study was designed to evaluate the efficacy and safety of a topical diclofenac sodium patch in the relief of pain and inflammation as a result of myofascial pain syndrome (MPS) in the upper trapezius. After sample size calculations indicated that 147 patients would be needed to detect a 25% difference between drug and control, 153 patients with MPS were recruited and randomized to receive either a diclofenac sodium patch or control (menthol) patch. Visual analog scale (VAS), cervical active range of motion, pressure pain threshold of the myofascial trigger point (MTrP), patient global assessment, Neck Disability Index, and the occurrence of adverse events were assessed on Day 0 (baseline), Day 4, and Day 8. Use of the diclofenac sodium patch elicited favorable responses for the VAS, cervical active range of motion, and Neck Disability Index by the end of the treatment course (P<0.05), and was consistently superior to the control patch at all time intervals. No significant differences were observed for the pressure pain threshold of the MTrP for either patch. Tolerability assessment similarly showed the diclofenac patch to be comparatively superior. When assessed at the end of the study, 20 diclofenac patch patients, but only four control patients, considered the tolerability of treatment to be "very good." Significant differences in adverse reactions were observed between the diclofenac and control patches, with the control patch more likely to produce overall skin irritation. This study demonstrate that the diclofenac sodium patch was superior to the control patch in terms of reducing pain and improving functional outcomes, and did not result in significant adverse effects.
(Copyright 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: J Pain Symptom Manage. 2010 Jun;39(6):e7-8. (PMID: 20538180)
المشرفين على المادة: 0 (Anti-Inflammatory Agents, Non-Steroidal)
144O8QL0L1 (Diclofenac)
تواريخ الأحداث: Date Created: 20091014 Date Completed: 20100419 Latest Revision: 20220316
رمز التحديث: 20221213
DOI: 10.1016/j.jpainsymman.2009.05.016
PMID: 19822404
قاعدة البيانات: MEDLINE
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