دورية أكاديمية
أعرض في EDS

Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey.

التفاصيل البيبلوغرافية
العنوان: Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey.
المؤلفون: Sintasath DM; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD 21205, USA. d.sintasath@malariaconsortium.org, Wolfe ND, Zheng HQ, LeBreton M, Peeters M, Tamoufe U, Djoko CF, Diffo JL, Mpoudi-Ngole E, Heneine W, Switzer WM
المصدر: Retrovirology [Retrovirology] 2009 Oct 27; Vol. 6, pp. 97. Date of Electronic Publication: 2009 Oct 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101216893 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-4690 (Electronic) Linking ISSN: 17424690 NLM ISO Abbreviation: Retrovirology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2004-
مواضيع طبية MeSH: Genome, Viral* , Sequence Analysis, DNA*, Cercopithecus/*virology , DNA, Viral/*genetics , Deltaretrovirus Infections/*veterinary , Simian T-lymphotropic virus 3/*genetics , Tumor Virus Infections/*veterinary, Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Walking ; Cluster Analysis ; DNA, Viral/chemistry ; Models, Molecular ; Molecular Sequence Data ; Nucleic Acid Conformation ; Phylogeny ; Polymerase Chain Reaction/methods ; Sequence Homology ; Simian T-lymphotropic virus 3/isolation & purification
مستخلص: Background: The recent discoveries of novel human T-lymphotropic virus type 3 (HTLV-3) and highly divergent simian T-lymphotropic virus type 3 (STLV-3) subtype D viruses from two different monkey species in southern Cameroon suggest that the diversity and cross-species transmission of these retroviruses are much greater than currently appreciated.
Results: We describe here the first full-length sequence of a highly divergent STLV-3d(Cmo8699AB) virus obtained by PCR-based genome walking using DNA from two dried blood spots (DBS) collected from a wild-caught Cercopithecus mona monkey. The genome of STLV-3d(Cmo8699AB) is 8913-bp long and shares only 77% identity to other PTLV-3s. Phylogenetic analyses using Bayesian and maximum likelihood inference clearly show that this highly divergent virus forms an independent lineage with high posterior probability and bootstrap support within the diversity of PTLV-3. Molecular dating of concatenated gag-pol-env-tax sequences inferred a divergence date of about 115,117 years ago for STLV-3d(Cmo8699AB) indicating an ancient origin for this newly identified lineage. Major structural, enzymatic, and regulatory gene regions of STLV-3d(Cmo8699AB) are intact and suggest viral replication and a predicted pathogenic potential comparable to other PTLV-3s.
Conclusion: When taken together, the inferred ancient origin of STLV-3d(Cmo8699AB), the presence of this highly divergent virus in two primate species from the same geographical region, and the ease with which STLVs can be transmitted across species boundaries all suggest that STLV-3d may be more prevalent and widespread. Given the high human exposure to nonhuman primates in this region and the unknown pathogenicity of this divergent PTLV-3, increased surveillance and expanded prevention activities are necessary. Our ability to obtain the complete viral genome from DBS also highlights further the utility of this method for molecular-based epidemiologic studies.
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معلومات مُعتمدة: K01 TW000003 United States TW FIC NIH HHS; DP1-OD000370 United States OD NIH HHS; 5 K01 TW000003-05 United States TW FIC NIH HHS; 2 D 43 TW000010-17-AITRP United States TW FIC NIH HHS; DP1 OD000370 United States OD NIH HHS
سلسلة جزيئية: GENBANK EU152281; EU231644; FJ957877; FJ957878; FJ957879; FJ957880; GQ241937
المشرفين على المادة: 0 (DNA, Viral)
تواريخ الأحداث: Date Created: 20091029 Date Completed: 20100113 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC2777865
DOI: 10.1186/1742-4690-6-97
PMID: 19860877
قاعدة البيانات: MEDLINE
الوصف
تدمد:1742-4690
DOI:10.1186/1742-4690-6-97