دورية أكاديمية
[Administration of premedication with fexofenadine for paclitaxel-induced hypersensitive reactions in breast cancer patients complicated with closed-angle glaucoma].
| العنوان: | [Administration of premedication with fexofenadine for paclitaxel-induced hypersensitive reactions in breast cancer patients complicated with closed-angle glaucoma]. |
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| المؤلفون: | Komatsubara K; Department of Pharmacy, National Hospital Organization Shikoku Cancer Center, Japan., Miyoshi K, Kogure Y, Matsuhisa T, Eguchi H |
| المصدر: | Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2010 Jan; Vol. 37 (1), pp. 107-10. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Gan To Kagaku Ryohosha Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]- |
| مواضيع طبية MeSH: | Anti-Allergic Agents/*therapeutic use , Antineoplastic Agents, Phytogenic/*adverse effects , Breast Neoplasms/*drug therapy , Drug Hypersensitivity/*prevention & control , Glaucoma, Angle-Closure/*complications , Paclitaxel/*adverse effects , Terfenadine/*analogs & derivatives, Breast Neoplasms/complications ; Female ; Humans ; Middle Aged ; Premedication ; Terfenadine/therapeutic use |
| مستخلص: | Paclitaxel (PTX) is one of the most important breast cancer treatment drugs. However, severe hypersensitivity reactions such as decreases in blood pressure and impaired breathing occur with high frequency. For the prevention of such hypersensitivity reactions, administration of a premedication composed of three components, diphenhydramine, ranitidine (or famotidine), and dexamethasone, has been advised in package insert information of medicine. Administration of diphenhydramine is difficult in breast cancer patients complicated with closed-angle glaucoma, because diphenhydramine has a weak anticholinergic adverse effect which can induce mydriasis and glaucoma attack. We studied the prevention of severe hypersensitivity reactions and of glaucoma attack in 2 breast cancer patients complicated with closed angle glaucoma at our hospital from April 2007 to March 2008. We switched from diphenhydramine to fexofenadine as the medicine to prevent hypersensitivity reactions. Hypersensitivity reactions were not observed throughout all courses in both patients, and no glaucoma attack was observed. |
| المشرفين على المادة: | 0 (Anti-Allergic Agents) 0 (Antineoplastic Agents, Phytogenic) 7BA5G9Y06Q (Terfenadine) E6582LOH6V (fexofenadine) P88XT4IS4D (Paclitaxel) |
| تواريخ الأحداث: | Date Created: 20100121 Date Completed: 20100225 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| PMID: | 20087041 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0385-0684 |
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