دورية أكاديمية
[Microbial population of lower respiratory tract in children from different age groups with cystic fibrosis].
| العنوان: | [Microbial population of lower respiratory tract in children from different age groups with cystic fibrosis]. |
|---|---|
| المؤلفون: | Shaginian IA, Kapranov NI, Chernukha MIu, Alekseeva GV, Semykin SIu, Avetisian LR, Kashirskaia NIu, Pivkina NV, Danilina GA, Batov AB, Busuek TP |
| المصدر: | Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2010 Jan-Feb (1), pp. 15-20. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Country of Publication: Russia (Federation) NLM ID: 0415217 Publication Model: Print Cited Medium: Print ISSN: 0372-9311 (Print) Linking ISSN: 03729311 NLM ISO Abbreviation: Zh Mikrobiol Epidemiol Immunobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2018, no. 4 (ii︠u︡lʹ-avgust)- >: Moskva : FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Original Publication: Moskva : Izd-vo "Medit︠s︡ina" |
| مواضيع طبية MeSH: | Cystic Fibrosis/*microbiology , Gram-Negative Bacteria/*isolation & purification , Lung/*microbiology , Respiratory Tract Infections/*microbiology , Staphylococcus aureus/*isolation & purification, Adolescent ; Child ; Child, Preschool ; Chronic Disease ; Cystic Fibrosis/complications ; Humans ; Infant ; Infant, Newborn ; Pseudomonas aeruginosa/isolation & purification ; Respiratory Tract Infections/complications ; Retrospective Studies ; Russia |
| مستخلص: | Aim: To study microflora of lower respiratory tract of children from different age groups with cystic fibrosis during follow-up for determination of its variability and possible sources of infectious complications. Materials and Methods: One hundred forty-one medical histories of patients from different age groups with cystic fibrosis living in various regions of Russian Federation were analyzed. Eighty-four children with cystic fibrosis living in Moscow and Moscow region treated as outpatients and inpatients were prospectively followed. For identification and characterization of microorganisms, microbiological, molecular biological, and statistical methods were used. Results: It was demonstrated that chronic pseudomonas, staphylococcal or mixed infection was already diagnosed in 25% of children aged 1-4 years, and identified in 80% of patients to the age of 18 years. In two-thirds of cases association of microorganisms was identified, and in hospitalized patients these associations were comprised by 3-5 microorganisms in 60% of cases. Aside from main agents in associations (Pseudomonas aeruginosa and Staphylococcus aureus), representatives of Gram-negative nonfermentative microorganisms (Burkholderia cepacia, Stenotrophomonas maltophilia, Acinetobacter baumanii) were often identified that possibly determined by tropism of these species to lung tissue. Conclusion: Chronic mixed infection is characteristic for patients with cystic fibrosis. Identification of possible mechanisms of lung infection in patients with cystic fibrosis will allow to develop evidence-based system of prevention of infectious complications in these patients. |
| تواريخ الأحداث: | Date Created: 20100312 Date Completed: 20100503 Latest Revision: 20201209 |
| رمز التحديث: | 20221213 |
| PMID: | 20218338 |
| قاعدة البيانات: | MEDLINE |
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