دورية أكاديمية
أعرض في EDS

Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome.

التفاصيل البيبلوغرافية
العنوان: Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome.
المؤلفون: Weijerman ME; Department of Paediatrics, Subdivision of General Paediatrics and Infectious Diseases, VU University Medical Center, Amsterdam, the Netherlands. weijerman@vumc.nl, van Furth AM, van der Mooren MD, van Weissenbruch MM, Rammeloo L, Broers CJ, Gemke RJ
المصدر: European journal of pediatrics [Eur J Pediatr] 2010 Oct; Vol. 169 (10), pp. 1195-9. Date of Electronic Publication: 2010 Apr 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1076 (Electronic) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Verlag
Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Down Syndrome/*epidemiology , Heart Defects, Congenital/*epidemiology , Persistent Fetal Circulation Syndrome/*epidemiology, Chi-Square Distribution ; Female ; Humans ; Incidence ; Infant, Newborn ; Male ; Netherlands/epidemiology ; Prevalence ; Prospective Studies ; Regression Analysis ; Statistics, Nonparametric
مستخلص: The aim of this study was to assess the prevalence of congenital heart defects (CHDs) and persistent pulmonary hypertension of the neonate (PPHN) in children with Down syndrome (DS) and to assess its impact on neonatal factors. It was a prospective study of a birth cohort of children with DS born between 2003 and 2006 registered by the Dutch Paediatric Surveillance Unit (DPSU). A CHD occurred in 43% of 482 children with trisomy 21. Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%. The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001). The reported mortality in newborns with DS was overall 3.3% and was still significant higher in children with a CHD versus no CHD (5.8% versus 1.5%) (p = 0.008). The presence of CHD in children with DS had no influence on their birth weight, mean gestational age and Apgar score. In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%. Early recognition of the cardiac condition of neonates with DS seems justified.
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تواريخ الأحداث: Date Created: 20100423 Date Completed: 20101223 Latest Revision: 20220318
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC2926442
DOI: 10.1007/s00431-010-1200-0
PMID: 20411274
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1076
DOI:10.1007/s00431-010-1200-0