دورية أكاديمية
أعرض في EDS

Alterations in adipose tissue during critical illness: An adaptive and protective response?

التفاصيل البيبلوغرافية
العنوان: Alterations in adipose tissue during critical illness: An adaptive and protective response?
المؤلفون: Langouche L; Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Belgium. lies.langouche@med.kuleuven.be, Perre SV, Thiessen S, Gunst J, Hermans G, D'Hoore A, Kola B, Korbonits M, Van den Berghe G
المصدر: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2010 Aug 15; Vol. 182 (4), pp. 507-16. Date of Electronic Publication: 2010 May 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : New York, NY : American Thoracic Society
Original Publication: New York, NY : American Lung Association, c1994-
مواضيع طبية MeSH: Critical Illness*, Adipose Tissue/*metabolism, Acetyl-CoA Carboxylase/metabolism ; Adaptation, Physiological ; Adipocytes/metabolism ; Aged ; Animals ; Biomarkers/metabolism ; Cadaver ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay/methods ; Fatty Acid Synthases/metabolism ; Female ; Glucokinase/metabolism ; Glucose/metabolism ; Humans ; Lipoprotein Lipase/metabolism ; Male ; Middle Aged ; Rabbits
مستخلص: Rationale: Critical illness is characterized by lean tissue wasting, whereas adipose tissue is preserved. Overweight and obese critically ill patients may have a lower risk of death than lean patients, suggestive of a protective role for adipose tissue during illness.
Objectives: To investigate whether adipose tissue could protectively respond to critical illness by storing potentially toxic metabolites, such as excess circulating glucose and triglycerides.
Methods: We studied adipose tissue morphology and metabolic activity markers in postmortem biopsies of 61 critically ill patients and 20 matched control subjects. Adipose morphology was also studied in in vivo biopsies of 27 patients and in a rabbit model of critical illness (n = 22).
Measurements and Main Results: Adipose tissue from critically ill patients revealed a higher number and a smaller size of adipocytes and increased preadipocyte marker levels as compared with control subjects. Virtually all adipose biopsies from critically ill patients displayed positive macrophage staining. The animal model demonstrated similar changes. Glucose transporter levels and glucose content were increased. Glucokinase expression was up-regulated, whereas glycogen and glucose-6-phosphate levels were low. Acetyl CoA carboxylase protein and fatty acid synthase activity were increased. Hormone-sensitive lipase activity was not altered, whereas lipoprotein lipase activity was increased. A substantially increased AMP-activated protein kinase activity may play a crucial role.
Conclusions: Postmortem adipose tissue biopsies from critically ill patients displayed a larger number of small adipocytes in response to critical illness, revealing an increased ability to take up circulating glucose and triglycerides. Similar morphologic changes were present in vivo. Such changes may render adipose tissue biologically active as a functional storage depot for potentially toxic metabolites, thereby contributing to survival.
المشرفين على المادة: 0 (Biomarkers)
EC 2.3.1.85 (Fatty Acid Synthases)
EC 2.7.1.2 (Glucokinase)
EC 3.1.1.34 (LPL protein, human)
EC 3.1.1.34 (Lipoprotein Lipase)
EC 6.4.1.2 (Acetyl-CoA Carboxylase)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20100506 Date Completed: 20100927 Latest Revision: 20151119
رمز التحديث: 20240628
DOI: 10.1164/rccm.200909-1395OC
PMID: 20442437
قاعدة البيانات: MEDLINE
الوصف
تدمد:1535-4970
DOI:10.1164/rccm.200909-1395OC