دورية أكاديمية
Inhaled magnesium fluoride reverse bronchospasma.
| العنوان: | Inhaled magnesium fluoride reverse bronchospasma. |
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| المؤلفون: | Gandia F; Laboratory of Physiology and Functional Explorations, CHU Farhat Hached, France. gandiafedoua1@yahoo.fr, Rouatbi S, Latiri I, Guénard H, Tabka Z |
| المصدر: | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi [J Smooth Muscle Res] 2010; Vol. 46 (3), pp. 157-64. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Dō Gakkai Country of Publication: Japan NLM ID: 9211664 Publication Model: Print Cited Medium: Internet ISSN: 1884-8796 (Electronic) Linking ISSN: 09168737 NLM ISO Abbreviation: J Smooth Muscle Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hirosaki-shi : Dō Gakkai, Heisei 3 [1991]- |
| مواضيع طبية MeSH: | Asthma/*drug therapy , Bronchodilator Agents/*administration & dosage , Fluorides/*administration & dosage , Magnesium Compounds/*administration & dosage, Administration, Inhalation ; Airway Resistance/drug effects ; Animals ; Bronchoconstriction/drug effects ; Magnesium Sulfate/administration & dosage ; Male ; Methacholine Chloride ; Rats ; Rats, Wistar ; Sodium Fluoride/administration & dosage |
| مستخلص: | Asthma is a global health problem. Asthma attacks are becoming more severe and more resistant to usual treatment by beta(2) agonists nebulisation. The search for a new product that could reduce the morbidity of asthmatic disease seems necessary. The objective of this study was to compare the effectiveness of inhaled magnesium fluoride (MgF(2)) with that of magnesium sulphate (MgSO(4)) 15% alone and sodium fluoride (NaF) 0.5 M alone in rats pre-contracted by methacholine (MeCh). Fifty six adult male Wistar rats of medium weight 259 +/- 15 g were divided randomly into five groups. They inhaled respectively: MeCh, MgF(2) + NaCl 0.9%, MgF(2) + acetic acid, MgSO(4) 15% single and NaF (0.5 M) single. Airway resistances were measured after each dose of MeCh by pneumomultitest equipment. Results indicated that (1) MgF(2) + NaCl 0.9%, MgF(2) + acetic acid and MgSO(4) reversed significantly the methacholine-induced bronchial constriction in rats and had a bronchodilating effect at the moment of its administration (2) MgF(2) + acetic acid led to a greater decrease (P<0.05) of bronchial resistances when compared to that obtained from MgF(2) + NaCl 0.9%, NaF exclusively and MgSO(4) alone (3) inhaled NaF alone led to a significant bronchorelaxing effect (P<0.05) that starts at the sixth dose of MeCh (17 mg/L). As a matter of fact, MgF(2) dissolved in acetic acid and delivered in aerosol form reduces significantly bronchial spasm. In conclusion, MgF(2) can be used as a bronchodilator for diseases with bronchospasma such as asthma and chronic obstructive pulmonary disease (COPD). |
| المشرفين على المادة: | 0 (Bronchodilator Agents) 0 (Magnesium Compounds) 0W5ETF9M2K (Methacholine Chloride) 5N014C7IWU (magnesium fluoride) 7487-88-9 (Magnesium Sulfate) 8ZYQ1474W7 (Sodium Fluoride) Q80VPU408O (Fluorides) |
| تواريخ الأحداث: | Date Created: 20100722 Date Completed: 20101103 Latest Revision: 20190608 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1540/jsmr.46.157 |
| PMID: | 20647692 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1884-8796 |
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| DOI: | 10.1540/jsmr.46.157 |