دورية أكاديمية
Diagnostic accuracy and feasibility of serological tests on filter paper samples for outbreak detection of T.b. gambiense human African trypanosomiasis.
| العنوان: | Diagnostic accuracy and feasibility of serological tests on filter paper samples for outbreak detection of T.b. gambiense human African trypanosomiasis. |
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| المؤلفون: | Hasker E; Institute of Tropical Medicine Antwerp, Belgium. ehasker@itg.be, Lutumba P, Mumba D, Lejon V, Büscher P, Kande V, Muyembe JJ, Menten J, Robays J, Boelaert M |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2010 Aug; Vol. 83 (2), pp. 374-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Disease Outbreaks*, Agglutination Tests/*standards , Enzyme-Linked Immunosorbent Assay/*standards , Trypanosoma brucei gambiense/*immunology , Trypanosomiasis, African/*diagnosis, Antibodies, Protozoan/blood ; Blood Specimen Collection/instrumentation ; Blood Specimen Collection/methods ; Democratic Republic of the Congo/epidemiology ; Filtration/instrumentation ; Humans ; Latex Fixation Tests/standards ; Monte Carlo Method ; Paper ; ROC Curve ; Sensitivity and Specificity ; Specimen Handling ; Trypanosomiasis, African/epidemiology |
| مستخلص: | Control of human African trypanosomiasis (HAT) in the Democratic Republic of Congo is based on mass population screening by mobile teams; a costly and labor-intensive approach. We hypothesized that blood samples collected on filter paper by village health workers and processed in a central laboratory might be a cost-effective alternative. We estimated sensitivity and specificity of micro-card agglutination test for trypanosomiasis (micro-CATT) and enzyme-linked immunosorbent assay (ELISA)/T.b. gambiense on filter paper samples compared with parasitology-based case classification and used the results in a Monte Carlo simulation of a lot quality assurance sampling (LQAS) approach. Micro-CATT and ELISA/T.b. gambiense showed acceptable sensitivity (92.7% [95% CI 87.4-98.0%] and 82.2% [95% CI 75.3-90.4%]) and very high specificity (99.4% [95% CI 99.0-99.9%] and 99.8% [95% CI 99.5-100%]), respectively. Conditional on high sample size per lot (> or = 60%), both tests could reliably distinguish a 2% from a zero prevalence at village level. Alternatively, these tests could be used to identify individual HAT suspects for subsequent confirmation. |
| References: | Trop Med Int Health. 2005 Apr;10(4):347-56. (PMID: 15807799) East Mediterr Health J. 2007 Sep-Oct;13(5):1098-107. (PMID: 18290403) Ann Soc Belg Med Trop. 1978;58(3):169-76. (PMID: 747425) Bull World Health Organ. 1991;69(5):603-6. (PMID: 1959162) Bull World Health Organ. 2002;80(11):882-6. (PMID: 12481210) World Health Organ Tech Rep Ser. 1998;881:I-VI, 1-114. (PMID: 10070249) Trop Med Int Health. 2002 Nov;7(11):942-8. (PMID: 12390600) Bull World Health Organ. 1998;76(6):559-64. (PMID: 10191551) Acta Trop. 1970;27(4):384-6. (PMID: 4396363) Ann Trop Med Parasitol. 2004 Jun;98(4):339-48. (PMID: 15228715) Trop Med Int Health. 2001 May;6(5):348-61. (PMID: 11348530) Acta Trop. 2003 Jan;85(1):31-7. (PMID: 12505181) Trans R Soc Trop Med Hyg. 1979;73(3):312-7. (PMID: 473329) Acta Trop. 1999 May 25;73(1):11-20. (PMID: 10379812) Biometrics. 1977 Mar;33(1):159-74. (PMID: 843571) Trop Med Int Health. 2004 May;9(5):542-50. (PMID: 15117297) Emerg Infect Dis. 2005 Sep;11(9):1382-8. (PMID: 16229766) Lancet. 2010 Jan 9;375(9709):148-59. (PMID: 19833383) Trop Med Int Health. 2001 May;6(5):342-7. (PMID: 11348529) Cancer. 1950 Jan;3(1):32-5. (PMID: 15405679) Trop Med Int Health. 2001 May;6(5):335-41. (PMID: 11348528) PLoS Med. 2008 Feb;5(2):e55. (PMID: 18303943) World Health Stat Q. 1991;44(3):133-9. (PMID: 1949880) Bull World Health Organ. 1991;69(5):603-8. (PMID: 1959163) Acta Trop. 1998 May;69(2):151-64. (PMID: 9588235) Emerg Infect Dis. 2007 Feb;13(2):248-54. (PMID: 17479887) |
| المشرفين على المادة: | 0 (Antibodies, Protozoan) |
| تواريخ الأحداث: | Date Created: 20100805 Date Completed: 20100908 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC2911188 |
| DOI: | 10.4269/ajtmh.2010.09-0735 |
| PMID: | 20682885 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
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| DOI: | 10.4269/ajtmh.2010.09-0735 |