دورية أكاديمية
Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides.
| العنوان: | Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides. |
|---|---|
| المؤلفون: | Maiorino M; Department of Biological Chemistry, University of Padova, Italy., Thomas JP, Girotti AW, Ursini F |
| المصدر: | Free radical research communications [Free Radic Res Commun] 1991; Vol. 12-13 Pt 1, pp. 131-5. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Harwood Academic Publishers Country of Publication: Switzerland NLM ID: 8709453 Publication Model: Print Cited Medium: Print ISSN: 8755-0199 (Print) Linking ISSN: 87550199 NLM ISO Abbreviation: Free Radic Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Yverdon-Les-Bains : Harwood Academic Publishers Original Publication: Chur ; New York : G+B/Harwood, c1985- |
| مواضيع طبية MeSH: | Lipid Peroxidation*, Glutathione Peroxidase/*metabolism , Lipid Peroxides/*metabolism , Lipoproteins, LDL/*metabolism , Liposomes/*metabolism , Membrane Lipids/*metabolism, Cholesterol/metabolism ; Dimyristoylphosphatidylcholine/metabolism ; Erythrocyte Membrane/metabolism ; Free Radicals ; Humans ; Phospholipid Hydroperoxide Glutathione Peroxidase |
| مستخلص: | A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposomes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX). While PHGPX reduces all hydroperoxides derived from phospholipids, cholesterol and cholesterol esters, GPX reduces only fatty acid hydroperoxides released after treatment of phospholipid hydroperoxides with phospholipase A2. These findings highlight the role of PHGPX in protecting biomembranes from peroxidative damage and add new insight into how cholesterol hydroperoxides are detossified in cells. |
| المشرفين على المادة: | 0 (Free Radicals) 0 (Lipid Peroxides) 0 (Lipoproteins, LDL) 0 (Liposomes) 0 (Membrane Lipids) 97C5T2UQ7J (Cholesterol) EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase) EC 1.11.1.9 (Glutathione Peroxidase) U86ZGC74V5 (Dimyristoylphosphatidylcholine) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 19910822 Latest Revision: 20191210 |
| رمز التحديث: | 20221208 |
| DOI: | 10.3109/10715769109145777 |
| PMID: | 2071029 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 8755-0199 |
|---|---|
| DOI: | 10.3109/10715769109145777 |