دورية أكاديمية
أعرض في EDS

Inhibitory effect of 5-hydroxytryptamine on penile erectile function in the rat.

التفاصيل البيبلوغرافية
العنوان: Inhibitory effect of 5-hydroxytryptamine on penile erectile function in the rat.
المؤلفون: Finberg JP; Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, Israel., Vardi Y
المصدر: British journal of pharmacology [Br J Pharmacol] 1990 Nov; Vol. 101 (3), pp. 698-702.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Print ISSN: 0007-1188 (Print) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Wiley
Original Publication: London, Macmillian Journals Ltd.
مواضيع طبية MeSH: Penile Erection/*drug effects , Serotonin/*pharmacology, Animals ; Blood Pressure/drug effects ; Decerebrate State ; Electric Stimulation ; Male ; Penile Erection/physiology ; Penis/blood supply ; Rats ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/physiology ; Serotonin/physiology ; Vasodilation/drug effects
مستخلص: 1. An increase in corporal pressure was elicited in pithed rats by stimulation of the sacral part of the spinal cord. This response was inhibited by intravenous injection of 5-hydroxytryptamine (5-HT) (ED50 = 28.5 +/- 2.2 micrograms kg-1). 2. The inhibitory effect of 5-HT was blocked by methysergide and methiothepin (each 1 mg kg-1), but not by ketanserin (0.02 mg kg-1), MDL 72222 (1 mg kg-1) or prazosin (0.1 mg kg-1). 3. An inhibitory effect on the corporal pressure response to spinal stimulation was also produced by 5-carboxyamidotryptamine (ED50 = 5.6 +/- 2.8 micrograms kg-1), but not by m-chlorophenylpiperazine (mCPP), RU 24969, 8-hydroxy-2-[di-n-propyl-amino]-tetralin (8-OH-DPAT) or fenfluramine (doses up to 1-2 mg kg-1). 4. Neither methiothepin (1 mg kg-1) nor clomipramine (1 mg kg-1) had any effect on the frequency-response curve for increase in corporal pressure by spinal stimulation. 5. The results indicate that 5-HT exerts an inhibitory action on penile erection by a peripheral mechanism. This effect may be mediated by vasoconstriction in cavernosal vessels, or inhibition of release of a vasodilator neurotransmitter. From the spectrum of agonist and antagonist responses, the receptor involved may be of the 5-HT1D subtype.
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المشرفين على المادة: 0 (Receptors, Serotonin)
333DO1RDJY (Serotonin)
تواريخ الأحداث: Date Created: 19901101 Date Completed: 19910422 Latest Revision: 20190510
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1917761
DOI: 10.1111/j.1476-5381.1990.tb14143.x
PMID: 2076486
قاعدة البيانات: MEDLINE
الوصف
تدمد:0007-1188
DOI:10.1111/j.1476-5381.1990.tb14143.x