دورية أكاديمية
Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania.
| العنوان: | Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania. |
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| المؤلفون: | Koehler RN; US Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland 20850, USA., Walsh AM, Saathoff E, Tovanabutra S, Arroyo MA, Currier JR, Maboko L, Hoelscher M, Robb ML, Michael NL, McCutchan FE, Kim JH, Kijak GH |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2010 Nov 15; Vol. 202 (10), pp. 1562-6. Date of Electronic Publication: 2010 Oct 05. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , HIV-1*, HIV Infections/*genetics , HIV Infections/*immunology , HLA-A Antigens/*genetics, Alleles ; Black People/genetics ; CD4 Lymphocyte Count ; Cohort Studies ; Disease Progression ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Tanzania/epidemiology |
| مستخلص: | Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4(+) cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection. |
| التعليقات: | Erratum in: J Infect Dis. 2011 Mar;203(5):749. Hoelsher, Michael [corrected to Hoelscher, Michael]. |
| معلومات مُعتمدة: | Y01 AI2642-12 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (HLA-A Antigens) |
| تواريخ الأحداث: | Date Created: 20101007 Date Completed: 20101122 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1086/656913 |
| PMID: | 20923372 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1086/656913 |