دورية أكاديمية
أعرض في EDS

Value of entheseal ultrasonography and serum cartilage oligomeric matrix protein in the preclinical diagnosis of psoriatic arthritis.

التفاصيل البيبلوغرافية
العنوان: Value of entheseal ultrasonography and serum cartilage oligomeric matrix protein in the preclinical diagnosis of psoriatic arthritis.
المؤلفون: Farouk HM; Internal Medicine and Rheumatology., Mostafa AA, Youssef SS, Elbeblawy MM, Assaf NY, Elokda el SE
المصدر: Clinical medicine insights. Arthritis and musculoskeletal disorders [Clin Med Insights Arthritis Musculoskelet Disord] 2010 Mar 29; Vol. 3, pp. 7-14. Date of Electronic Publication: 2010 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101542737 Publication Model: Electronic Cited Medium: Internet ISSN: 1179-5441 (Electronic) Linking ISSN: 11795441 NLM ISO Abbreviation: Clin Med Insights Arthritis Musculoskelet Disord Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2016- > : Thousand Oaks, CA : SAGE Publications
Original Publication: [Auckland, N.Z.] : Libertas Academica
مستخلص: Objective: To evaluate the utility of entheseal ultrasonography and serum COMP in the preclinical diagnosis of psoriatic arthritis.
Methods: 60 psoriatic patients were divided into: 30 patients with psoriasis (group I) and 30 patients with psoriatic arthritis as control (group II). They underwent independent clinical and ultrasonographic examination of both lower limbs at the calcaneal insertions of Achilles tendons. Psoriatic arthritis disease activity and severity was assessed by modified DAS28 and Steinbrockers scores. Serum levels of COMP were measured for all patients by ELISA.
Results: On clinical examination, no entheseal abnormalities were detected in group I while they were present in 23.3% of group II with statistically significant difference between them (P < 0.001). Ultrasonographic entheseal abnormalities were detected in 33.3% of group I and in 46.7% of group II with no significant difference between them (P > 0.05). Serum COMP were significantly elevated in group I and II with no statistically significant difference between them (mean ± SD 5.9 ± 3 and 6.8 ± 12 respectively, P > 0.05). Entheseal ultrasound was more specific (67%) while serum COMP was more sensitive (87%) in the preclinical diagnosis of psoriatic arthritis. Serum COMP levels were significantly correlated with CRP in both groups and with DAS28 and Steinbrockers scores in group II (P < 0.01).
Conclusion: Entheseal ultrasonography and serum COMP levels may be used complementary to each other for preclinical diagnosis of psoriatic arthritis. Serum COMP seems to be promising prognostic marker for psoriatic arthritis patients.
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فهرسة مساهمة: Keywords: cartilage oligomeric matrix protein; entheseal ultrasound; psoriasis; psoriatic arthritis
تواريخ الأحداث: Date Created: 20101203 Date Completed: 20110714 Latest Revision: 20211020
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC2989640
DOI: 10.4137/cmamd.s4461
PMID: 21124691
قاعدة البيانات: MEDLINE
الوصف
تدمد:1179-5441
DOI:10.4137/cmamd.s4461