دورية أكاديمية
أعرض في EDS

Autonomic dysfunction predicts early cardiac affection in patients with systemic sclerosis.

التفاصيل البيبلوغرافية
العنوان: Autonomic dysfunction predicts early cardiac affection in patients with systemic sclerosis.
المؤلفون: Othman KM; The Departments of Cardiology., Assaf NY, Farouk HM, Aly Hassan IM
المصدر: Clinical medicine insights. Arthritis and musculoskeletal disorders [Clin Med Insights Arthritis Musculoskelet Disord] 2010 May 24; Vol. 3, pp. 43-54. Date of Electronic Publication: 2010 May 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101542737 Publication Model: Electronic Cited Medium: Internet ISSN: 1179-5441 (Electronic) Linking ISSN: 11795441 NLM ISO Abbreviation: Clin Med Insights Arthritis Musculoskelet Disord Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2016- > : Thousand Oaks, CA : SAGE Publications
Original Publication: [Auckland, N.Z.] : Libertas Academica
مستخلص: Objective: To detect the early preclinical alterations in cardiac autonomic control as well as altered cardiac function in systemic sclerosis (SSc) patients and their relevance to the clinical features of the disease using noninvasive methods.
Methods: 30 SSc patients and 15 healthy controls matched for age and sex underwent clinical examination, serological analysis, and echocardiographic assessment including Doppler flow imaging to evaluate cardiac function, and 24-hour Holter monitoring analyzed for arrhythmia and heart rate variability (HRV) in the time and frequency domains.
Results: The trans-mitral Doppler of early to atrial wave (E/A) ratio was reversed in five patients (16.6%) and the tricuspid E/A ratio was reversed in 10 patients (33.3%). Holter analysis for SSc patients revealed an increased prevalence of premature ventricular contractions (PVC) ≥ 10/h (P = 0.02), supra-ventricular tachycardias (SVTs) (P = 0.2), and total PVC count (P = 0.0000). Highly significant (P = 0.000) impairment in all HRV parameters was demonstrated in the SSc patients. Total skin thickness score (TSS), Raynaud's phenomenon and anti-scleroderma 70 (anti-SCL70) showed significant positive correlations with all arrhythmia parameters, while showing a significant negative correlation with the impaired ventricular diastolic function and various HRV parameters. No correlation was found between arrhythmia and HRV parameters and disease duration, disease type, or presence of anti-centromere antibodies.
Conclusion: Low heart rate variability, increased TSS and the presence of anti-SCL70 are correlated with preclinical cardiac involvement in SSc patients and may predict the likelihood of malignant arrhythmia and sudden cardiac death. Therefore, noninvasive HRV evaluation before clinical cardiac involvement in these patients might be beneficial when added to the clinical and laboratory assessments in detecting high-risk patients, and may allow for implementation of preventive measures and initiation of appropriate therapy early in the course of the disease.
References: Am J Cardiol. 1991 Sep 1;68(6):626-30. (PMID: 1877480)
J Rheumatol. 1988 Feb;15(2):202-5. (PMID: 3361530)
Dig Dis Sci. 2001 Apr;46(4):723-30. (PMID: 11330404)
J Hypertens Suppl. 1984 Dec;2(3):S383-5. (PMID: 6599685)
Ann Med Interne (Paris). 2002 May;153(3):167-78. (PMID: 12218899)
Ann Rheum Dis. 2000 Feb;59(2):94-8. (PMID: 10666162)
Eur J Echocardiogr. 2005 Dec;6(6):407-18. (PMID: 16293527)
Eur J Intern Med. 2009 Jul;20(4):378-82. (PMID: 19524178)
J Nucl Med. 2001 Feb;42(2):183-8. (PMID: 11216514)
J Am Soc Echocardiogr. 2003 Oct;16(10):1091-110. (PMID: 14566308)
Rheumatology (Oxford). 2010 Feb;49(2):355-60. (PMID: 20007288)
J Am Coll Cardiol. 1996 Apr;27(5):1053-60. (PMID: 8609321)
Lupus. 2005;14(9):702-7. (PMID: 16218471)
J Rheumatol. 2009 Jan;36(1):191-6. (PMID: 19040309)
Science. 1981 Jul 10;213(4504):220-2. (PMID: 6166045)
Rinsho Byori. 2006 Apr;54(4):325-8. (PMID: 16722449)
Arch Cardiovasc Dis. 2010 Jan;103(1):46-52. (PMID: 20142120)
Rheumatology (Oxford). 2002 May;41(5):586-8. (PMID: 12011386)
Circulation. 1991 Aug;84(2):482-92. (PMID: 1860193)
J Rheumatol. 1994 Oct;21(10):1849-54. (PMID: 7837149)
J Rheumatol. 1996 Apr;23(4):643-5. (PMID: 8730119)
Am J Cardiol. 1998 Dec 1;82(11):1323-8. (PMID: 9856913)
Circulation. 1996 Mar 1;93(5):1043-65. (PMID: 8598068)
Ital Heart J. 2004 Nov;5(11):831-9. (PMID: 15633438)
Int J Immunopathol Pharmacol. 2005 Oct-Dec;18(4):609-14. (PMID: 16388707)
J Rheumatol. 1995 Jul;22(7):1281-5. (PMID: 7562759)
Circulation. 1991 Mar;83(3):945-52. (PMID: 1999042)
Br Heart J. 1994 Jan;71(1):3-6. (PMID: 8297689)
Psychophysiology. 1991 Mar;28(2):201-16. (PMID: 1946886)
Am J Cardiol. 1999 Aug 15;84(4):440-8. (PMID: 10468084)
Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii45-8. (PMID: 19487224)
Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv39-42. (PMID: 16980722)
Br J Rheumatol. 1997 Jun;36(6):669-76. (PMID: 9236677)
J Am Coll Cardiol. 1989 Nov 1;14(5):1139-48. (PMID: 2681319)
Clin Rev Allergy Immunol. 2011 Apr;40(2):92-103. (PMID: 20087791)
Arthritis Rheum. 1980 May;23(5):581-90. (PMID: 7378088)
J Rheumatol. 2000 Mar;27(3):692-7. (PMID: 10743810)
Clin Sci (Lond). 1999 Jan;96(1):49-57. (PMID: 9857106)
J Rheumatol. 2010 May;37(5):993-9. (PMID: 20194451)
Autoimmunity. 2009 Nov;42(7):587-95. (PMID: 19863377)
Ann Noninvasive Electrocardiol. 2009 Jul;14(3):251-7. (PMID: 19614636)
Am J Cardiol. 1989 Nov 15;64(18):1162-7. (PMID: 2816768)
Br Heart J. 1991 Jan;65(1):14-9. (PMID: 1704246)
Chest. 2005 Aug;128(2):755-63. (PMID: 16100164)
فهرسة مساهمة: Keywords: autonomic dysfunction; heart rate variability; systemic sclerosis
تواريخ الأحداث: Date Created: 20101203 Date Completed: 20110714 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC2989638
DOI: 10.4137/cmamd.s4940
PMID: 21124695
قاعدة البيانات: MEDLINE
الوصف
تدمد:1179-5441
DOI:10.4137/cmamd.s4940