[Importance of early detection of lung cancers with initial paraneoplastic manifestations].

التفاصيل البيبلوغرافية
العنوان:	[Importance of early detection of lung cancers with initial paraneoplastic manifestations].
المؤلفون:	Vukić V; Pulmonary Department, Clinic for Internal Medicine, Clinical Hospital Centre 'Bezanijska kosa', Belgrade, Serbia., Skodrić-Trifunović V, Gvozdenović BS, Jovanović D, Zunić M, Djurić D
المصدر:	Srpski arhiv za celokupno lekarstvo [Srp Arh Celok Lek] 2010 Sep-Oct; Vol. 138 (9-10), pp. 595-9.
نوع المنشور:	English Abstract; Journal Article
اللغة:	Serbian
بيانات الدورية:	Publisher: Srpski Lekarski Drustvo Country of Publication: Serbia NLM ID: 0027440 Publication Model: Print Cited Medium: Print ISSN: 0370-8179 (Print) Linking ISSN: 03708179 NLM ISO Abbreviation: Srp Arh Celok Lek Subsets: MEDLINE
أسماء مطبوعة:	Publication: Beograd : Srpski Lekarski Drustvo Original Publication: Belgrade.
مواضيع طبية MeSH:	Carcinoma, Non-Small-Cell Lung/diagnosis , Lung Neoplasms/diagnosis , Paraneoplastic Syndromes/diagnosis , Small Cell Lung Carcinoma/diagnosis, Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Early Detection of Cancer ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Paraneoplastic Syndromes/pathology ; Paraneoplastic Syndromes/therapy ; Small Cell Lung Carcinoma/pathology ; Small Cell Lung Carcinoma/therapy
مستخلص:	Introduction: Lung cancers are mostly detected in the developed clinical stages, with clearly manifested pulmonary, extrapulmonary or metastatic manifestations. In the early disease stages, radiographic and clinical manifestations may be absent or mimicked. Objective: The aim of this study was the timely detection of early pulmonary, extrapulmonary and paraneoplastic manifestations of lung cancers in order to apply the most appropriate treatment protocols. Methods: We examined 230 patients with lung cancer, among them 125 of the working study group with minimal pulmonary and/or initial paraneoplastic symptoms, and 105 patients in the control group with clear tumour manifestations. Results: The symptom analysis revealed a statistically significantly lesser presence of the respiratory symptoms in the working study group (68%) in comparison with the control group of patients (97%) (chi2 = 29.996; p < 0.001). The analysis of radiographic presentations of lung cancer showed that there were significantly more patients with normal findings in the working group (6.4%) than in the control group--1.9% (p > 0.05), and a positive bronchoscopic finding of the centrally localized tumour (mainly right upper lobe) was confirmed in patients of both groups with normal radiographic findings. The number of diagnosed patients in earlier clinical disease stages (I, II, IIIa) with better prognosis in non-small cell lung cancer was significantly higher (chi2 = 19.149; p < 0.001) in the working group (71.1%) in comparison with the control group (38.1%). Small cell lung cancer was more frequently diagnosed in the stage of limited disease in the working (80%) than in the control group (38.1%) (chi2 = 10.039; p < 0.05). With regard to treatment administration, there is a statistically significant difference (chi2 = 4.013; p = 0.0452) in the frequency between the use of chemotherapy and highly significant difference (chi2 = 22.044; p < 0.001) in the frequency of use of surgical treatment in the working group in comparison with the control group--both chemotherapy and surgery treatment were more frequent in the patients of the working group. Conclusion: Recognizing the initial pulmonary, extrapulmonary or paraneoplastic manifestations as well as performing diagnostic procedures in due time represent the most important guidelines in early detection and the most efficacious therapeutic choice in lung cancer.
تواريخ الأحداث:	Date Created: 20101225 Date Completed: 20110120 Latest Revision: 20190918
رمز التحديث:	20231215
DOI:	10.2298/sarh1010595v
PMID:	21180089
قاعدة البيانات:	MEDLINE

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تدمد:	0370-8179
DOI:	10.2298/sarh1010595v