دورية أكاديمية
[Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues].
| العنوان: | [Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues]. |
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| المؤلفون: | Li G; Department of Chest Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R.China., Dai J, Wang Y, Chen G, Liu X, Miao F, Bai L, Chen Y |
| المصدر: | Zhongguo fei ai za zhi = Chinese journal of lung cancer [Zhongguo Fei Ai Za Zhi] 2002 Feb 20; Vol. 5 (1), pp. 35-7. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo fei ai za zhi bian ji wei yuan hui Country of Publication: China NLM ID: 101126433 Publication Model: Print Cited Medium: Print ISSN: 1009-3419 (Print) Linking ISSN: 10093419 NLM ISO Abbreviation: Zhongguo Fei Ai Za Zhi Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2008- : Tianjin Shi : Zhongguo fei ai za zhi bian ji wei yuan hui Original Publication: Chendu Shi : Zhongguo fei ai za zhi bian ji wei yuan hui |
| مستخلص: | Background: To investigate the expression level and its clinical significance of the multi-drug resistance (MDR) associated protein in lung cancer specimens. Methods: The expression levels of Pgp, MRP, GST-π and TopoII of MDR associated protein were detected in 60 lung cancer samples and 30 paracancerous tissues by S-P immunohistochemistry method. Results: The positive rate of Pgp, MRP, GST-π and Topo II in the lung cancer tissues was 40.0% (24/60), 61.7% (37/60), 45.0% (27/60) and 81.7% (49/60) respectively, which was significantly higher than those in paracancerous tissues (P < 0.01). No significant correlation was observed among the expression of multi-drug resistance-related protein and TNM staging, pathological type, cell differention and lymph node metastasis status (P > 0.05). Conclusions: Lung cancer has overexpression of multi-drug resistant-related genes during the oncogenesis. Combined detection of these genes may be useful for guiding the lung cancer chemotherapy. |
| تواريخ الأحداث: | Date Created: 20110215 Date Completed: 20121002 Latest Revision: 20110214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3779/j.issn.1009-3419.2002.01.10 |
| PMID: | 21315026 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1009-3419 |
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| DOI: | 10.3779/j.issn.1009-3419.2002.01.10 |