دورية أكاديمية
[Conventional dose of prednisone regulates Th-associated gene expression in de novo ITP patients].
| العنوان: | [Conventional dose of prednisone regulates Th-associated gene expression in de novo ITP patients]. |
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| المؤلفون: | Li F; Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200031, China., Wu BT, Wang WG, Zhan YX, Zou SH, Cheng YF |
| المصدر: | Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2011 Feb; Vol. 19 (1), pp. 197-201. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN: 1009-2137 (Print) Linking ISSN: 10092137 NLM ISO Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhongguo shi yan xue za zhi she, |
| مواضيع طبية MeSH: | Glucocorticoids/*therapeutic use , Purpura, Thrombocytopenic, Idiopathic/*metabolism , Purpura, Thrombocytopenic, Idiopathic/*pathology, Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Forkhead Transcription Factors/metabolism ; Gene Expression ; Gene Expression Regulation ; Humans ; Interferon-gamma/metabolism ; Interleukin-2/metabolism ; Male ; Middle Aged ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; T-Box Domain Proteins/metabolism ; T-Lymphocytes, Helper-Inducer/metabolism ; Transforming Growth Factor beta/metabolism ; Young Adult |
| مستخلص: | This study was aimed to investigate the T cell (helper T cells) immune status in ITP patients and its relation with therapeutic response. 20 de novo ITP patients were enrolled (8 males, 12 females) with a median age of 41 (20 to 81). Real-time RT-PCR method was used to measure the gene expression of Th cells including T-bet, IFN-γ, GATA-3, TGF-β, Foxp3, IL-2, IL-4 in PBMNC of ITP patients before and after conventional dose of prednisone therapy [1 mg/(kg·d)] and in PBMNC of 20 normal controls. The results showed that T-bet, IFN-γ and IL-2 were significantly over-expressed in PBMNC of ITP patients before treatment compared with that in normal controls (p < 0.01), and compared with that before treatment, T-bet, IFN-γ, and IL-2 were markedly down-regulated in ITP patients after treatment. Before treatment, the expressions of Foxp3, TGF-β, GATA3 and IL-4 in ITP patients did not show difference from normal controls, while after treatment Foxp3 were more up-regulated than that before treatment (p < 0.05). After treatment, TGF-β expression showed a different pattern between old and young patients. TGF-β expression was down-regulated (p < 0.05) among ITP patients younger than 60, while up-regulated in older patients. It is concluded that there is an imbalance of Th1/Th2/Treg cytokines in ITP patients, which can be reversed by glucocorticoid treatment. The conventional dose of glucocorticoid may be regarded as effective therapy for de novo ITP patients, it may correlate with improvement of imbalance between Th1/The2/Treg cytokines. |
| المشرفين على المادة: | 0 (FOXP3 protein, human) 0 (Forkhead Transcription Factors) 0 (Glucocorticoids) 0 (Interleukin-2) 0 (T-Box Domain Proteins) 0 (T-box transcription factor TBX21) 0 (Transforming Growth Factor beta) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20110303 Date Completed: 20121217 Latest Revision: 20161018 |
| رمز التحديث: | 20231215 |
| PMID: | 21362251 |
| قاعدة البيانات: | MEDLINE |
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