دورية أكاديمية
أعرض في EDS

Is inflammatory bowel disease an important risk factor among older persons with colorectal cancer in the United States? A population-based case-control study.

التفاصيل البيبلوغرافية
العنوان: Is inflammatory bowel disease an important risk factor among older persons with colorectal cancer in the United States? A population-based case-control study.
المؤلفون: Shaukat A; Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section 111-D, 1- Veterans Drive, Minneapolis, MN 55417, USA. shaukat@umn.edu, Virnig DJ, Salfiti NI, Howard DH, Sitaraman SV, Liff JM
المصدر: Digestive diseases and sciences [Dig Dis Sci] 2011 Aug; Vol. 56 (8), pp. 2378-83. Date of Electronic Publication: 2011 Mar 16.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York, NY : Springer Science + Business Media
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Colorectal Neoplasms/*epidemiology , Inflammatory Bowel Diseases/*epidemiology, Aged ; Aged, 80 and over ; Case-Control Studies ; Colorectal Neoplasms/etiology ; Female ; Humans ; Incidence ; Inflammatory Bowel Diseases/complications ; Male ; Prevalence ; Risk Factors ; United States/epidemiology
مستخلص: Background: While ulcerative colitis (UC) and Crohn's disease (CD) are thought to predispose to colorectal cancer (CRC), the association has not been well studied in an older population.
Aims: The objective of our study was to evaluate the association of ulcerative colitis and Crohn's disease and colorectal cancer in a population-based, case-control study. We also wished to estimate the incidence rates of colorectal cancer among older individuals with UC/CD.
Methods: All cases of colorectal cancer in persons 67 and older in the SEER catchment area and in the Medicare claims database were compared with cancer-free controls residing in the same geographic area. We used multivariable logistic regression models adjusted for demographic and other factors.
Results: We identified 47,543 cases of CRC and 142,273 controls. We found a modest association between UC and CRC (OR 1.93; 95% CI 1.54-2.49; P-value<0.001) and a significant, albeit modest, association between CD and CRC (OR 1.45; 95% CI 1.08-1.91; P-value 0.01). We found the incidence of CRC to be 8.2 per 10,000 person-years (95% CI 6.5-10.1/10,000 person-years) among those with UC/CD, and 6.1 per 10,000 person-years (95% CI 4.6-7.8/10,000 person-years) among those without UC/CD, resulting in an incidence rate ratio of 1.34.
Conclusions: Among older persons ulcerative colitis and Crohn's disease are modest risk factors for CRC, and the incidence rate ratio for CRC is modest, suggesting that risk of CRC in patients with IBD may be lower than previously thought.
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تواريخ الأحداث: Date Created: 20110317 Date Completed: 20111013 Latest Revision: 20211020
رمز التحديث: 20231215
DOI: 10.1007/s10620-011-1632-z
PMID: 21409378
قاعدة البيانات: MEDLINE
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