دورية أكاديمية
أعرض في EDS

The human POMC gene promoter: where do we stand?

التفاصيل البيبلوغرافية
العنوان: The human POMC gene promoter: where do we stand?
المؤلفون: Pecori Giraldi F; University of Milan, Milan, Italy. fpg@auxologico.it, Cassarino F, Pagliardini L, Asnaghi V, Cavagnini F
المصدر: Journal of endocrinological investigation [J Endocrinol Invest] 2011 Jun; Vol. 34 (6), pp. 454-60. Date of Electronic Publication: 2011 Mar 21.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Berlin : Springer
Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis.
مواضيع طبية MeSH: Gene Expression Regulation*, Pro-Opiomelanocortin/*genetics , Promoter Regions, Genetic/*genetics , Transcription, Genetic/*genetics, Humans
مستخلص: Proopiomelanocortin (POMC) is crucial for several life-essential functions and its regulation has been studied extensively in the past decades. The first studies provided the framework for POMC promoter activity, namely the identification for the major response elements contained in the promoter, e.g., the glucocorticoid response element, the Nur response element, while subsequent studies showed the importance of cooperation and interplay between transcription factors to achieve optimal promoter activity. The involvement of constitutive repressors of POMC transcription, such as Bmp4, provided the latest clues to our understanding of POMC promoter activity. This increased knowledge benefits the clinician as it allows genetic testing and early recognition of patients with congenital ACTH deficiency due to mutations in TPIT and paves the way to new medical treatments in Cushing's disease. The present review will illustrate the current standing on regulation of the human POMC promoter, focusing on its activity in corticotropes.
References: J Clin Invest. 1999 Nov;104(9):1277-85. (PMID: 10545526)
J Clin Invest. 1995 Mar;95(3):1288-98. (PMID: 7883977)
Mol Cell Biol. 1997 Nov;17(11):6673-82. (PMID: 9343431)
Endocrinology. 2002 Oct;143(10):3916-24. (PMID: 12239103)
J Clin Endocrinol Metab. 1999 Feb;84(2):440-8. (PMID: 10022398)
Mol Cell Biol. 1991 Jul;11(7):3492-503. (PMID: 2046665)
J Mol Endocrinol. 1991 Feb;6(1):53-61. (PMID: 2015057)
Mol Cell Endocrinol. 1999 Jan 25;147(1-2):93-102. (PMID: 10195696)
J Mol Endocrinol. 2001 Feb;26(1):43-9. (PMID: 11174853)
FEBS Lett. 2004 Apr 9;563(1-3):229-33. (PMID: 15063754)
Eur J Pharmacol. 2007 Mar 8;558(1-3):1-6. (PMID: 17196958)
J Biol Chem. 2005 May 20;280(20):19746-56. (PMID: 15767262)
Mol Endocrinol. 1994 Oct;8(10):1377-88. (PMID: 7854355)
J Endocrinol Invest. 2005 Dec;28(11):1015-8. (PMID: 16483181)
Endocrinology. 2004 Feb;145(2):867-80. (PMID: 14576184)
Endocrinology. 1998 May;139(5):2209-16. (PMID: 9564824)
Mol Cell Biol. 1997 Oct;17(10):5952-9. (PMID: 9315653)
Genes Dev. 2006 Oct 15;20(20):2871-86. (PMID: 17043312)
Gene. 1989 Dec 7;84(1):115-26. (PMID: 2558057)
Neuroimmunomodulation. 2002-2003;10(5):310-6. (PMID: 12759568)
FEBS Lett. 1981 Nov 30;135(1):97-102. (PMID: 6274691)
FASEB J. 2005 Feb;19(2):281-3. (PMID: 15572433)
Mol Endocrinol. 1997 Jan;11(1):39-47. (PMID: 8994186)
Mol Endocrinol. 2005 May;19(5):1329-42. (PMID: 15695370)
Endocrinology. 2006 Jan;147(1):247-56. (PMID: 16195406)
Mol Endocrinol. 1990 Nov;4(11):1737-43. (PMID: 2177842)
J Neuroendocrinol. 2006 Apr;18(4):273-8. (PMID: 16503922)
J Clin Invest. 2001 Oct;108(8):1123-31. (PMID: 11602619)
J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):59-63. (PMID: 9699858)
J Clin Endocrinol Metab. 2005 Mar;90(3):1323-31. (PMID: 15613420)
J Endocrinol. 2008 Nov;199(2):177-89. (PMID: 18715881)
Mol Endocrinol. 2004 Dec;18(12):2997-3010. (PMID: 15319449)
EMBO J. 1993 Jan;12(1):145-56. (PMID: 8428574)
Mol Endocrinol. 1989 Jan;3(1):215-23. (PMID: 2536890)
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7261-5. (PMID: 3478693)
Neuroimmunomodulation. 2004;11(4):224-32. (PMID: 15249728)
Biochem J. 1995 Dec 15;312 ( Pt 3):827-32. (PMID: 8554527)
Genes Dev. 1996 May 15;10(10):1284-95. (PMID: 8675014)
J Biol Chem. 2004 Mar 19;279(12):10837-40. (PMID: 14711817)
Mol Endocrinol. 2009 Jan;23(1):47-60. (PMID: 19036902)
Mol Cell Biol. 1999 Nov;19(11):7549-57. (PMID: 10523643)
Reg Anesth Pain Med. 2007 Jan-Feb;32(1):60-6. (PMID: 17196494)
J Endocrinol. 2007 May;193(2):279-90. (PMID: 17470519)
J Endocrinol. 2006 Feb;188(2):321-31. (PMID: 16461558)
Eur J Biochem. 1983 Jul 1;133(3):599-605. (PMID: 6305652)
Mol Endocrinol. 2001 Feb;15(2):338-48. (PMID: 11158338)
Diabetes Metab Res Rev. 2007 May;23(4):317-23. (PMID: 16921546)
J Neuroendocrinol. 1994 Dec;6(6):627-37. (PMID: 7894465)
Endocr J. 2008 May;55(2):285-90. (PMID: 18323674)
J Endocrinol. 1998 Jan;156(1):169-75. (PMID: 9496246)
Oncogene. 1999 Apr 22;18(16):2627-33. (PMID: 10353606)
DNA Cell Biol. 1995 Feb;14(2):103-10. (PMID: 7865128)
J Biol Chem. 2003 Nov 21;278(47):46523-32. (PMID: 12970370)
Mol Endocrinol. 1995 Jun;9(6):745-55. (PMID: 8592520)
Mol Cell Biol. 1997 Oct;17(10):5946-51. (PMID: 9315652)
Endocrinology. 2010 Mar;151(3):1129-41. (PMID: 20056821)
Exp Clin Endocrinol. 1993;101(1):36-8. (PMID: 8386673)
J Endocrinol. 2005 May;185(2):337-43. (PMID: 15845926)
Endocrinology. 2007 Jan;148(1):422-32. (PMID: 17038560)
Pituitary. 1998 Apr;1(1):33-43. (PMID: 11081181)
Neuroimmunomodulation. 2010;17(2):88-96. (PMID: 19923853)
J Mol Endocrinol. 1994 Jun;12(3):365-82. (PMID: 7916974)
Mol Cell Biol. 1993 Apr;13(4):2342-53. (PMID: 8455616)
J Biol Chem. 1997 Apr 18;272(16):10551-7. (PMID: 9099700)
J Clin Invest. 2000 Dec;106(11):1417-25. (PMID: 11104795)
Mol Endocrinol. 1998 Nov;12(11):1708-20. (PMID: 9817597)
Endocrinology. 2010 Aug;151(8):3697-705. (PMID: 20555024)
Horm Res. 2007;67(5):257-62. (PMID: 17220632)
Endocrinology. 1998 May;139(5):2414-22. (PMID: 9564853)
Anesthesiology. 2003 May;98(5):1172-7. (PMID: 12717139)
Cell. 1998 May 15;93(4):531-41. (PMID: 9604929)
Mol Endocrinol. 2002 Jul;16(7):1638-51. (PMID: 12089357)
Nucleic Acids Res. 1990 Aug 11;18(15):4513-21. (PMID: 2388831)
Mol Endocrinol. 2007 Nov;21(11):2738-49. (PMID: 17698954)
Endocrinology. 2000 Sep;141(9):3313-8. (PMID: 10965903)
المشرفين على المادة: 66796-54-1 (Pro-Opiomelanocortin)
تواريخ الأحداث: Date Created: 20110406 Date Completed: 20141113 Latest Revision: 20211020
رمز التحديث: 20240829
DOI: 10.3275/7613
PMID: 21464606
قاعدة البيانات: MEDLINE
الوصف
تدمد:1720-8386
DOI:10.3275/7613