دورية أكاديمية
أعرض في EDS

Current source density measures of electroencephalographic alpha predict antidepressant treatment response.

التفاصيل البيبلوغرافية
العنوان: Current source density measures of electroencephalographic alpha predict antidepressant treatment response.
المؤلفون: Tenke CE; Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA. tenkecr@pi.cpmc.columbia.edu, Kayser J, Manna CG, Fekri S, Kroppmann CJ, Schaller JD, Alschuler DM, Stewart JW, McGrath PJ, Bruder GE
المصدر: Biological psychiatry [Biol Psychiatry] 2011 Aug 15; Vol. 70 (4), pp. 388-94. Date of Electronic Publication: 2011 Apr 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Brain Mapping*, Alpha Rhythm/*drug effects , Antidepressive Agents/*pharmacology , Depression/*drug therapy , Fluoxetine/*pharmacology, Adult ; Alpha Rhythm/physiology ; Analysis of Variance ; Antidepressive Agents/therapeutic use ; Electroencephalography ; Female ; Fluoxetine/therapeutic use ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Principal Component Analysis ; Treatment Outcome ; Young Adult
مستخلص: Background: Despite recent success in pharmacologic treatment of depression, the inability to predict individual treatment response remains a liability. This study replicates and extends findings relating pretreatment electroencephalographic (EEG) alpha to treatment outcomes for serotonergic medications.
Methods: Resting EEG (eyes-open and eyes-closed) was recorded from a 67-electrode montage in 41 unmedicated depressed patients and 41 healthy control subjects. Patients were tested before receiving antidepressants including a serotonergic mode of action (selective serotonin reuptake inhibitor [SSRI], serotonin and norepinephrine reuptake inhibitor, or SSRI plus norepinephrine and dopamine reuptake inhibitor). EEG was quantified by frequency principal components analysis of spectra derived from reference-free current source density (CSD) waveforms, which sharpens and simplifies EEG topographies, disentangles them from artifact, and yields measures that more closely represent underlying neuronal current generators.
Results: Patients who did not respond to treatment had significantly less alpha CSD compared with responders or healthy control subjects, localizable to well-defined posterior generators. The alpha difference between responders and nonresponders was greater for eyes-closed than eyes-open conditions and was present across alpha subbands. A classification criterion based on the median alpha for healthy control subjects showed good positive predictive value (93.3) and specificity (92.3). There was no evidence of differential value for predicting response to an SSRI alone or dual treatment targeting serotonergic plus other monoamine neurotransmitters.
Conclusions: Findings confirm the value of EEG alpha amplitude as a viable predictor of antidepressant response and suggest that personalized treatments for depression may be identified using simple electrophysiologic CSD measures.
(Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 MH036295 United States MH NIMH NIH HHS; R01 MH036295-27 United States MH NIMH NIH HHS; MH36295 United States MH NIMH NIH HHS
المشرفين على المادة: 0 (Antidepressive Agents)
01K63SUP8D (Fluoxetine)
تواريخ الأحداث: Date Created: 20110422 Date Completed: 20111129 Latest Revision: 20220418
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3142299
DOI: 10.1016/j.biopsych.2011.02.016
PMID: 21507383
قاعدة البيانات: MEDLINE
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