دورية أكاديمية
Serum lipoprotein levels in takotsubo cardiomyopathy vs. myocardial infarction.
| العنوان: | Serum lipoprotein levels in takotsubo cardiomyopathy vs. myocardial infarction. |
|---|---|
| المؤلفون: | Gaddam S; Department of Internal Medicine, Staten Island University Hospital, New York, USA. gaddamsainath@gmail.com., Nimmagadda KC, Nagrani T, Naqi M, Wetz RV, Weiserbs KF, McCord D, Ghavami F, Gala B, Lafferty JC |
| المصدر: | International archives of medicine [Int Arch Med] 2011 Apr 28; Vol. 4, pp. 14. Date of Electronic Publication: 2011 Apr 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: iMedPub Country of Publication: England NLM ID: 101317943 Publication Model: Electronic Cited Medium: Internet ISSN: 1755-7682 (Electronic) Linking ISSN: 17557682 NLM ISO Abbreviation: Int Arch Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : London iMedPub Original Publication: London : BioMed Central, 2008- |
| مستخلص: | Background: In the setting of myocardial infarction (MI) or acute coronary syndrome (ACS), current guidelines recommend early and aggressive lipid lowering therapy with statins, irrespective of the baseline lipoprotein levels. Takotsubo cardiomyopathy (TCM) patients have a clinical presentation similar to myocardial infarction and thus receive early and aggressive statin therapy during their initial hospitalization. However, the pathology of TCM is not atherosclerotic coronary artery disease and hence we assumed the lipid profiles in TCM would be healthier than coronary artery disease patients. Methods: In this retrospective study, we assessed fasting serum lipoprotein levels of ten TCM patients and compared them with forty, age and sex-matched myocardial infarction (MI) patients. Results: Comparing serum lipoprotein levels of TCM with MI group, there was no significant difference in mean total cholesterol between the two groups (174.5 mg/dL vs. 197.6 mg/dL, p = 0.12). However, in the TCM group, mean HDL-C was significantly higher (66.87 mg/dL vs. 36.5 mg/dL, p = 0.008), the mean LDL-C was significantly lower (89.7 mg/dL vs. 128.9 mg/dL, p = 0.0002), and mean triglycerides was also significantly lower (65.2 mg/dL vs. 166.8 mg/dL, p < 0.0001). Conclusions: In this study, TCM patients in comparison to MI patients had significantly higher levels of HDL-C, lower levels of LDL-C levels and triglycerides. The lipid profiles in TCM were consistent with the underlying pathology of non-atherosclerotic, non-obstructive coronary artery disease. As lipoproteins in most TCM patients were within the optimal range, we recommend an individual assessment of lipid profiles along with their coronary heart disease risk factors for considering long term lipid-lowering therapy. A finding of hyperalphalipoproteinemia or hypotriglyceridemia in 40% of TCM patients is novel but this association needs to be confirmed in future studies with larger sample sizes. These findings may provide clues in understanding the pathogenesis of takotsubo cardiomyopathy. |
| References: | Circulation. 2002 Dec 17;106(25):3143-421. (PMID: 12485966) Int J Cardiol. 2008 Jun 23;127(1):121-3. (PMID: 17544159) JAMA. 2004 Sep 15;292(11):1307-16. (PMID: 15337732) Postgrad Med J. 1988 May;64(751):352-6. (PMID: 3200776) MedGenMed. 2003 Aug 07;5(3):20. (PMID: 14600656) N Engl J Med. 2005 Feb 10;352(6):539-48. (PMID: 15703419) Am J Cardiol. 2006 Nov 15;98(10):1379-82. (PMID: 17134633) J Am Coll Cardiol. 2003 Mar 5;41(5):743-8. (PMID: 12628716) J Am Coll Cardiol. 2001 Jul;38(1):11-8. (PMID: 11451258) J Am Coll Cardiol. 2009 Dec 15;54(25):2358-62. (PMID: 20082923) Br Heart J. 1995 Jul;74(1):18-20. (PMID: 7662447) Circulation. 2008 Dec 16;118(25):2754-62. (PMID: 19106400) Atherosclerosis. 1980 Apr;35(4):433-7. (PMID: 7378123) Wien Klin Wochenschr. 2010 Mar;122(5-6):184-5. (PMID: 20361383) Br Med J (Clin Res Ed). 1984 Dec 15;289(6459):1651-3. (PMID: 6439361) Am J Med. 1977 May;62(5):707-14. (PMID: 193398) J Nucl Cardiol. 2006 Mar-Apr;13(2):244-50. (PMID: 16580961) |
| تواريخ الأحداث: | Date Created: 20110430 Date Completed: 20110714 Latest Revision: 20220410 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3094218 |
| DOI: | 10.1186/1755-7682-4-14 |
| PMID: | 21527016 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder كن أول من يترك تعليقا!