دورية أكاديمية
[Expression of CD133 in the bone marrow of patients with myelodysplastic syndrome and its clinical significance].
| العنوان: | [Expression of CD133 in the bone marrow of patients with myelodysplastic syndrome and its clinical significance]. |
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| المؤلفون: | Zhong LY; Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, China. zhongliye99@163.com, DU X, Geng SX, Weng JY, Zheng HT, Wu SJ, Li YQ |
| المصدر: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2011 May; Vol. 31 (5), pp. 854-5. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou : Nanfang yi ke da xue xue bao bian ji bu, 2005- |
| مواضيع طبية MeSH: | Antigens, CD/*metabolism , Glycoproteins/*metabolism , Myelodysplastic Syndromes/*diagnosis , Myelodysplastic Syndromes/*metabolism , Peptides/*metabolism, AC133 Antigen ; Anemia, Aplastic/metabolism ; Antigens, CD34/metabolism ; Female ; Flow Cytometry ; Humans ; Male ; Middle Aged |
| مستخلص: | Objective: To investigate the expression of CD133 in the bone marrow of patients with myelodysplastic syndrome (MDS) and explore its clinical significance. Methods: The expression of CD133 and CD34/CD38 in the bone marrow was detected using flow cytometry in 31 cases of refractory anemia with excess blasts (RAEB), 10 cases of refractory cytopenia with multilineage dysplasia (RCMD) and 11 cases of aplastic anemia (AA). Results: The percentage of CD133-expressing cells was 6.75% in patients with RAEB, significantly higher than that in patients with RCMD (1.41%) and AA (2.70%) (P<0.05); the percentage of CD133-positive cells were similar between the latter two patient groups (P>0.05). The percentage of CD34(+)/CD38- cells was similar in the 3 groups (P>0.05), all lower than 1%. Conclusions: Advanced MDS patients are characterized by an increase of CD133-expressing cells, suggesting the value of CD133 in the diagnosis of RAEB. CD34(+)/CD38- cells do not show a significant value in the diagnosis of MDS. |
| المشرفين على المادة: | 0 (AC133 Antigen) 0 (Antigens, CD) 0 (Antigens, CD34) 0 (Glycoproteins) 0 (PROM1 protein, human) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20110524 Date Completed: 20130304 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| PMID: | 21602141 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1673-4254 |
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