دورية أكاديمية
Cyclosporin abrogates virus-specific T-cell control of EBV-induced B-cell lymphoproliferation.
| العنوان: | Cyclosporin abrogates virus-specific T-cell control of EBV-induced B-cell lymphoproliferation. |
|---|---|
| المؤلفون: | York LJ; Department of Microbiology, University of Saskatchewan, Saskatoon, Canada., Qualtiere LF |
| المصدر: | Viral immunology [Viral Immunol] 1990 Summer; Vol. 3 (2), pp. 127-36. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 8801552 Publication Model: Print Cited Medium: Print ISSN: 0882-8245 (Print) Linking ISSN: 08828245 NLM ISO Abbreviation: Viral Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Mary Ann Liebert, Inc., c1987- |
| مواضيع طبية MeSH: | B-Lymphocytes/*immunology , Cyclosporins/*pharmacology , Herpesvirus 4, Human/*immunology , Lymphocyte Activation/*drug effects , T-Lymphocytes/*drug effects, Animals ; B-Lymphocytes/microbiology ; Cell Line, Transformed ; Clone Cells ; Cytotoxicity, Immunologic/immunology ; Flow Cytometry ; Humans ; In Vitro Techniques ; Receptors, Interleukin-2/biosynthesis ; Receptors, Interleukin-2/drug effects ; Sheep ; T-Lymphocytes/immunology |
| مستخلص: | Renal and cardiac recipients undergoing aggressive immunosuppressive therapy with cyclosporin A have been reported to have unusually high incidences of Epstein-Barr virus (EBV) genome-positive lymphomas. T cells have been shown to be of critical importance in controlling the lymphoproliferative potential of the EB virus. EBV-specific T cell clones were generated in vitro by repeated antigenic restimulation in the presence of interleukin-2 (IL-2). These virus-specific cells were used to study cyclosporin A's effect on their activation, proliferation and cytotoxic function, and the possible abrogation of the cell's ability to control virus-induced lymphoproliferation. In this study, we show that cyclosporin A does not interfere with antigen recognition, since the T cell cytotoxic potential is unchanged. However, cyclosporin A induces a dose-dependent reduction in membrane IL-2 receptor expression which consequently limits the proliferation of the antigen-activated cell. This may translate in vivo to an insufficient expansion of the cytotoxic T cells which controls the outgrowth of the EBV-infected B cell. |
| المشرفين على المادة: | 0 (Cyclosporins) 0 (Receptors, Interleukin-2) |
| تواريخ الأحداث: | Date Created: 19900101 Date Completed: 19900808 Latest Revision: 20141120 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/vim.1990.3.127 |
| PMID: | 2163257 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0882-8245 |
|---|---|
| DOI: | 10.1089/vim.1990.3.127 |