دورية أكاديمية
Haematological side effects of antiepileptic drug treatment in patients with epilepsy.
| العنوان: | Haematological side effects of antiepileptic drug treatment in patients with epilepsy. |
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| المؤلفون: | Bachmann T; Department of Neurology, Oslo University Hospital-Rikshospitalet, Oslo, Norway. bachmann_tanja@hotmail.com, Bertheussen KH, Svalheim S, Rauchenzauner M, Luef G, Gjerstad L, Taubøll E |
| المصدر: | Acta neurologica Scandinavica. Supplementum [Acta Neurol Scand Suppl] 2011 (191), pp. 23-7. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 0370337 Publication Model: Print Cited Medium: Internet ISSN: 1600-5449 (Electronic) Linking ISSN: 00651427 NLM ISO Abbreviation: Acta Neurol Scand Suppl Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Copenhagen : Wiley-Blackwell Original Publication: Copenhagen Munksgaard |
| مواضيع طبية MeSH: | Anticonvulsants/*adverse effects , Carbamazepine/*adverse effects , Epilepsy/*drug therapy , Piracetam/*analogs & derivatives , Triazines/*adverse effects , Valproic Acid/*adverse effects, Adolescent ; Adult ; Anticonvulsants/pharmacology ; Blood Platelets/drug effects ; Carbamazepine/pharmacology ; Cross-Sectional Studies ; Epilepsy/blood ; Female ; Humans ; Lamotrigine ; Leukocytes/drug effects ; Levetiracetam ; Male ; Middle Aged ; Piracetam/adverse effects ; Piracetam/pharmacology ; Platelet Count ; Triazines/pharmacology ; Valproic Acid/pharmacology |
| مستخلص: | Objectives: Little is known about the haematological side effects of the newer antiepileptic drugs (AEDs), but recent case reports have raised concerns regarding the possibility of altered thrombocyte counts or function in some patients during levetiracetam (LEV) treatment. The aim of our study was to investigate haematological changes in patients treated with the newer AEDs, LEV and lamotrigine (LTG), compared with the older AEDs, valproate (VPA) and carbamazepine (CBZ). Methods: This cross-sectional study included 251 patients with epilepsy of both genders, aged 18-45 years, using AED monotherapy: 52 patients on LEV (31 men, 21 women), 80 on LTG (37 men, 43 women), 90 on CBZ (61 men, 29 women), 29 on VPA (15 men, 14 women), and 79 healthy controls (36 men, 43 women). Haemoglobin (Hb), white blood cells (WBC) and platelet (thrombocyte) counts were estimated. The subjects were recruited from hospitals in south-eastern Norway and Innsbruck, Austria. Results: Significantly lower platelet counts were recorded in both men and women on LEV monotherapy. In the LEV group, platelets were 14% lower (40.68 × 10(9) /l lower) than in the control group. There was no difference according to sex or age of the patients. Only minor changes in haematological parameters were observed for the other drugs investigated. Conclusions: Both men and women treated with LEV monotherapy have lower blood platelet counts than healthy controls, with no difference in Hb or WBC. Haematological changes observed with the other AEDs were minor. (© 2011 John Wiley & Sons A/S.) |
| المشرفين على المادة: | 0 (Anticonvulsants) 0 (Triazines) 33CM23913M (Carbamazepine) 44YRR34555 (Levetiracetam) 614OI1Z5WI (Valproic Acid) U3H27498KS (Lamotrigine) ZH516LNZ10 (Piracetam) |
| تواريخ الأحداث: | Date Created: 20110630 Date Completed: 20111111 Latest Revision: 20220330 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/j.1600-0404.2011.01539.x |
| PMID: | 21711253 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1600-5449 |
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| DOI: | 10.1111/j.1600-0404.2011.01539.x |