دورية أكاديمية
Secondary leprosy infection in a patient with psoriasis during treatment with infliximab.
| العنوان: | Secondary leprosy infection in a patient with psoriasis during treatment with infliximab. |
|---|---|
| المؤلفون: | Teixeira FM; Posgraduation Program of Biotechnology (RENORBIO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, Ceara, Brazil. briciamt@yahoo.com.br, Vasconcelos LM, Rola Cde A, Prata de Almeida TL, Valença JT Jr, Nagao-Dias AT |
| المصدر: | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2011 Aug; Vol. 17 (5), pp. 269-71. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9518034 Publication Model: Print Cited Medium: Internet ISSN: 1536-7355 (Electronic) Linking ISSN: 10761608 NLM ISO Abbreviation: J Clin Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : Lippincott Williams & Wilkins Original Publication: Baltimore, MD : Williams & Wilkins, c1995- |
| مواضيع طبية MeSH: | Antibodies, Monoclonal/*adverse effects , Antibodies, Monoclonal/*therapeutic use , Leprosy, Borderline/*diagnosis , Leprosy, Borderline/*microbiology , Psoriasis/*drug therapy , Tumor Necrosis Factor-alpha/*antagonists & inhibitors, Antitubercular Agents/therapeutic use ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infliximab ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Leprostatic Agents/therapeutic use ; Leprosy, Borderline/drug therapy ; Male ; Middle Aged ; Mycobacterium leprae ; Mycobacterium tuberculosis ; Opportunistic Infections/diagnosis ; Opportunistic Infections/drug therapy ; Opportunistic Infections/microbiology |
| مستخلص: | Tumor necrosis factor α antagonists are proven to be effective for the treatment of chronic inflammatory conditions, such as psoriasis. A major concern for patients is the risk of acquiring granulomatous infectious diseases caused by the immunosuppressive effects of the drugs. We report a 60-year-old man with psoriasis who underwent infliximab treatment for 2 years and developed secondary leprosy, presenting extensive erythematous and infiltrated plaques on the trunk and limbs with loss of sensitivity (thermal, pain and tactile). The skin lesion biopsy showed perivascular epithelioid granulomas, nodular dermal aggregates of foamy macrophages and bundles of acid-fast bacilli. The clinical picture associated with histopathologic evaluation suggested borderline lepromatous leprosy. Before infliximab treatment, the patient had a positive tuberculin skin test and underwent chemoprophylaxis treatment for latent tuberculosis. Although the tuberculin reactivity suggests a strong correlation with a latent Mycobacterium tuberculosis infection, the possibility of infections by other mycobacteria, such as Mycobacterium leprae, should not be discarded. |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antitubercular Agents) 0 (Immunosuppressive Agents) 0 (Leprostatic Agents) 0 (Tumor Necrosis Factor-alpha) B72HH48FLU (Infliximab) |
| تواريخ الأحداث: | Date Created: 20110723 Date Completed: 20111220 Latest Revision: 20151119 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/RHU.0b013e3182288870 |
| PMID: | 21778902 |
| قاعدة البيانات: | MEDLINE |
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