دورية أكاديمية
Risk factors of gastrointestinal and hepatic adverse drug reactions in the treatment of rheumatoid arthritis with biomedical combination therapy and Chinese medicine.
| العنوان: | Risk factors of gastrointestinal and hepatic adverse drug reactions in the treatment of rheumatoid arthritis with biomedical combination therapy and Chinese medicine. |
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| المؤلفون: | Jiang M; Institute of Basic Research In Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China., Zha Q, He Y, Lu A |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2012 Jun 01; Vol. 141 (2), pp. 615-21. Date of Electronic Publication: 2011 Jul 18. |
| نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Integrative Medicine* , Medicine, Chinese Traditional*, Antirheumatic Agents/*adverse effects , Arthritis, Rheumatoid/*drug therapy , Chemical and Drug Induced Liver Injury/*etiology , Drugs, Chinese Herbal/*adverse effects , Gastrointestinal Diseases/*chemically induced, Adult ; Chi-Square Distribution ; China ; Drug Interactions ; Drug Therapy, Combination ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome |
| مستخلص: | Ethnopharmacological Relevance: The exploration of risk factors on the gastrointestinal adverse drug reactions (GI ADRs) and hepatic ADRs in the treatment of rheumatoid arthritis (RA) with traditional Chinese medicien (CM) and convertional Western Medicien (WM) therapy will benifit the clincial drug administration. Methods: A multi-center, randomized-clinical trial was conducted on RA patients in China. After 12 and 24 weeks of treatment, the efficacy and safety of WM therapy and CM therapy were evaluated. The Chi-square and logistic regression were conducted to analyze the correlations between the biological parameters, CM symptoms and the ADRs. Results: 505 patients were recruited from 9 centers and randomly assigned into WM therapy group (n=251) or CM group (n=254). 397 of them completed the 24 week treatment (194 in WM and 203 in CM group). Total ADRs incidence and withdrawal rates were similar in two groups. For the patients treated with WM, logistic regression analysis showed that CRP level was negatively related to GI ADRs (p<0.05), dizziness was positively related to GI ADRs (p<0.05); and IgG level and chills were positively related to hepatic ADRs (p<0.01, p<0.05). In the patients treated with CM, no laboratory measurements were found related with GI ADRs and hepatic ADRs, lassitude and nocturia were risk factors for GI ADRs, cold extremities for hepatic ADRs, respectively (p<0.05). Conclusion: CRP in normal scale and dizziness were the risk factors for GI ADRs, higher IgG level and chills were the risk factors for hepatic ADRs in the RA patients treated with conventional WM therapy. Lassitude and nocturia were the risk factors for GI ADRs, and cold extremities were the risk factors for hepatic ADRs in the RA patients treated with CM therapy. (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Antirheumatic Agents) 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20110726 Date Completed: 20120928 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jep.2011.07.026 |
| PMID: | 21782923 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2011.07.026 |