دورية أكاديمية
أعرض في EDS

Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.

التفاصيل البيبلوغرافية
العنوان: Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.
المؤلفون: Pinheiro EM; Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB
المصدر: Nature cell biology [Nat Cell Biol] 2011 Jul 24; Vol. 13 (8), pp. 989-95. Date of Electronic Publication: 2011 Jul 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Macmillan Magazines Ltd., [1999-
مواضيع طبية MeSH: Nerve Tissue Proteins/*physiology , Neurogenesis/*physiology , Pyramidal Cells/*physiology , Serum Response Factor/*physiology, Animals ; Base Sequence ; Cell Movement/physiology ; Female ; Gene Knockdown Techniques ; Mice ; Models, Neurological ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/genetics ; Pregnancy ; RNA, Small Interfering/genetics
مستخلص: During corticogenesis, pyramidal neurons (∼80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia, and then migrate to their proper position within the cortex. As pyramidal neurons migrate radially, they remain attached to their glial substrate as they pass through the subventricular and intermediate zones, regions rich in tangentially migrating interneurons and axon fibre tracts. We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode.
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معلومات مُعتمدة: GM068678 United States GM NIGMS NIH HHS; F32-GM074507 United States GM NIGMS NIH HHS; F32 GM074507 United States GM NIGMS NIH HHS; United States HHMI Howard Hughes Medical Institute; R01 GM068678-08 United States GM NIGMS NIH HHS; R01 GM068678 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Nerve Tissue Proteins)
0 (RNA, Small Interfering)
0 (Serum Response Factor)
تواريخ الأحداث: Date Created: 20110726 Date Completed: 20110929 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3149714
DOI: 10.1038/ncb2292
PMID: 21785421
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4679
DOI:10.1038/ncb2292