دورية أكاديمية
Successful twin pregnancy outcome after in utero exposure to FOLFOX for metastatic colon cancer: a case report and review of the literature.
| العنوان: | Successful twin pregnancy outcome after in utero exposure to FOLFOX for metastatic colon cancer: a case report and review of the literature. |
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| المؤلفون: | Jeppesen JB; Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Hvidovre, Denmark. johannejj@hotmail.com, Østerlind K |
| المصدر: | Clinical colorectal cancer [Clin Colorectal Cancer] 2011 Dec; Vol. 10 (4), pp. 348-52. Date of Electronic Publication: 2011 Jul 30. |
| نوع المنشور: | Case Reports; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101120693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0674 (Electronic) Linking ISSN: 15330028 NLM ISO Abbreviation: Clin Colorectal Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2011-> : [New York] : Elsevier Original Publication: Dallas, Tex. : Cancer Information Group, c2001- |
| مواضيع طبية MeSH: | Pregnancy Outcome* , Pregnancy, Twin*, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Colonic Neoplasms/*drug therapy , Liver Neoplasms/*drug therapy , Pregnancy Complications, Neoplastic/*drug therapy, Adult ; Colonic Neoplasms/pathology ; Female ; Fluorouracil/therapeutic use ; Humans ; Leucovorin/therapeutic use ; Liver Neoplasms/secondary ; Magnetic Resonance Imaging ; Organoplatinum Compounds/therapeutic use ; Pregnancy ; Pregnancy Complications, Neoplastic/pathology |
| مستخلص: | There is limited experience in treating advanced colorectal cancer diagnosed during pregnancy because it is a rare occurrence; however, the incidence of colorectal cancer complicating pregnancy is expected to increase in the future. The combination of cancer and pregnancy is complicated and causes many dilemmas and concerns for the physician and patient. A delay in treatment may compromise maternal survival; however, therapy for the cancer may be harmful to the fetus. We present a case of a 26-year-old woman pregnant with twins who was diagnosed with metastatic colon cancer and treated with 5-fluorouracil, leukovorin, and oxaliplatin (FOLFOX) from 13 weeks gestational age to birth. The patient gave birth to healthy twins without malformations at 33 weeks gestational age. At follow-up examination, the 2-year-old twins are developing normally. The patient herself died 1 year after the initial cancer diagnosis. This shows a case in which the administration of FOLFOX during the second and third trimester of pregnancy caused no fetal harm. These findings are similar to those of previous studies in which systemic chemotherapy administered during the second and third trimester was relatively safe. However, we know that chemotherapy should be avoided during the first trimester. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Organoplatinum Compounds) Q573I9DVLP (Leucovorin) U3P01618RT (Fluorouracil) |
| SCR Protocol: | Folfox protocol |
| تواريخ الأحداث: | Date Created: 20110802 Date Completed: 20120320 Latest Revision: 20230221 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clcc.2011.06.003 |
| PMID: | 21803658 |
| قاعدة البيانات: | MEDLINE |
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