دورية أكاديمية
أعرض في EDS

Risk factors of post renal transplant anaemia among Sudanese patients, a study in three renal transplant centres.

التفاصيل البيبلوغرافية
العنوان: Risk factors of post renal transplant anaemia among Sudanese patients, a study in three renal transplant centres.
المؤلفون: Banaga AS; Department of Medicine & Nephrology, University of Medical Sciences and Technology, Sudan. amin.banaga@gmail.com, Yousif ME, Elmusharaf K
المصدر: BMC nephrology [BMC Nephrol] 2011 Aug 09; Vol. 12, pp. 37. Date of Electronic Publication: 2011 Aug 09.
نوع المنشور: Comparative Study; Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Anemia/*ethnology , Kidney Transplantation/*adverse effects , Kidney Transplantation/*ethnology , Postoperative Complications/*ethnology, Adult ; Anemia/etiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/etiology ; Risk Factors ; Sudan/ethnology ; Time Factors
مستخلص: Background: There is a relative lack of recent information about late post kidney transplantation anaemia (PTA), especially in the developing countries; data are scarce about the prevalence and risk factors of PTA. Sudan was a leading country in Africa and Arab world in kidney transplantation. The first kidney transplantation in Sudan was in 1973.
Methods: This is a cross-sectional hospital analytic study enrolling all kidney transplanted recipients following in the transplant referral clinics at Ahmed Gassim, Selma and Ibn Sina Hospitals, Khartoum/Sudan, in the period from 1/8/2010 to 1/9/2010, clinical and laboratory data were obtained from 114 patients, anaemia was defined as Hb levels of < 13 g/dl for male patients and < 12 g/dl for female patients, exclusion criteria were pregnancy, below 18 years old patients, multiple organ transplantation, and patients with less than one year from the transplantation.
Results: The study showed that 39.5% of the patients were anaemic. Univariate analysis showed that late PTA is significantly associated with not using Erythropoietin (EPO) in the pre-transplant period (p = < 0.001), history of rejection (p = 0.003), longer time from transplantation (p = 0.015), and eGFR (p < 0.0001). Multivariate analysis showed that eGFR (p = < 0.001) and not use of EPO in the pre transplant period (p < 0.001) are strong predictors of PTA. The use of Angiotensin converting enzyme inhibitors/Angiotensin receptors blockers (ACEI/ARB), immunosuppressive treatments, presence or absence of co-morbidities, donor type and donor age are not significantly associated with late PTA.
Conclusion: The study concluded that late PTA is common and under recognized. Risk factors for late PTA include renal dysfunction, history of rejection, longer duration of transplantation and not using EPO in the pre-transplant period. Renal dysfunction and not using EPO in the pre-transplant period are major predictors of late PTA.
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تواريخ الأحداث: Date Created: 20110811 Date Completed: 20120525 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3162485
DOI: 10.1186/1471-2369-12-37
PMID: 21827693
قاعدة البيانات: MEDLINE
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