دورية أكاديمية
Neutrophil-derived cathelicidin protects from neointimal hyperplasia.
| العنوان: | Neutrophil-derived cathelicidin protects from neointimal hyperplasia. |
|---|---|
| المؤلفون: | Soehnlein O; Institute for Cardiovascular Prevention, Ludwig-Maximilians University München, Munich 80336, Germany. oliver.soehnlein@med.uni-muenchen.de, Wantha S, Simsekyilmaz S, Döring Y, Megens RT, Mause SF, Drechsler M, Smeets R, Weinandy S, Schreiber F, Gries T, Jockenhoevel S, Möller M, Vijayan S, van Zandvoort MA, Agerberth B, Pham CT, Gallo RL, Hackeng TM, Liehn EA, Zernecke A, Klee D, Weber C |
| المصدر: | Science translational medicine [Sci Transl Med] 2011 Oct 05; Vol. 3 (103), pp. 103ra98. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Antimicrobial Cationic Peptides/*therapeutic use , Hyperplasia/*prevention & control , Neointima/*prevention & control , Neutrophils/*metabolism, Animals ; Antimicrobial Cationic Peptides/chemistry ; Apolipoproteins E/genetics ; Atherosclerosis/surgery ; Cells, Cultured ; Drug-Eluting Stents ; Mice ; Mice, Knockout ; Cathelicidins |
| مستخلص: | Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy. |
| التعليقات: | Comment in: Nat Rev Drug Discov. 2011 Dec;10(12):902. (PMID: 22129987) |
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| معلومات مُعتمدة: | R01 AI049261 United States AI NIAID NIH HHS; R01 AI049261-09 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Antimicrobial Cationic Peptides) 0 (Apolipoproteins E) 0 (Cathelicidins) |
| تواريخ الأحداث: | Date Created: 20111007 Date Completed: 20120501 Latest Revision: 20221207 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3246402 |
| DOI: | 10.1126/scitranslmed.3002531 |
| PMID: | 21974936 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1946-6242 |
|---|---|
| DOI: | 10.1126/scitranslmed.3002531 |