دورية أكاديمية
أعرض في EDS

Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients.

التفاصيل البيبلوغرافية
العنوان: Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients.
المؤلفون: Kacso I; Department of Nephrology, University of Medicine and Pharmacy 'Iuliu Hatieganu' Cluj Napoca, 3-5 Clinicilor Street, 400006 Cluj Napoca, Romania., Lenghel A, Bondor CI, Moldovan D, Rusu C, Nita C, Hancu N, Gherman Caprioara M, Kacso G
المصدر: International urology and nephrology [Int Urol Nephrol] 2012 Aug; Vol. 44 (4), pp. 1151-7. Date of Electronic Publication: 2011 Oct 13.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Springer
Original Publication: Budapest, Akademiai Kiadó
مواضيع طبية MeSH: Adiponectin/*blood , Albuminuria/*metabolism , Creatinine/*blood , Creatinine/*urine , Diabetes Mellitus, Type 2/*metabolism , Diabetic Nephropathies/*metabolism, Albuminuria/complications ; Body Mass Index ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/physiopathology ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Kidney Function Tests ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Time Factors
مستخلص: Background: Experimental studies have shown that adiponectin has antiproteinuric and nephroprotective effects. The purpose of the study was to assess the value of plasma adiponectin as a predictor of proteinuria in type 2 diabetes (T2D) patients.
Methods: In this one-year prospective follow-up study, we included T2D patients with positive visual test for microalbuminuria (Micral) and negative visual test for proteinuria. Exclusion criteria were: glomerular filtration ratio (GFR) < 30 ml/min, acute infection/inflammation, uncontrolled hypertension, and atherosclerotic complications. The main outcome measure was the change in urinary albumin/creatinine ratio (UACR) after 1 year follow-up (Δ UACR).
Results: Fifty-six patients (66% males) completed the study. Their initial mean UACR was 81.58 ± 26.42 mg/g and mean GFR was 81.15 ± 3.96 ml/min. At baseline, simple regression disclosed significant correlations between UACR and plasma adiponectin (r = 0.54, P = 0.00002) and GFR (r = -0.28, P = 0.03); in multiple regression analysis, plasma adiponectin remained the only predictor of UACR (P = 0.00007). Baseline plasma adiponectin was significantly correlated to body mass index (r = -0.28, P = 0.04), waist circumference (r = -0.27, P = 0.05), HDL cholesterol (r = 0.35, P = 0.01), and LDL cholesterol (r = 0.27, P = 0.04). Baseline plasma adiponectin significantly correlated in simple (r = -0.38, P = 0.004) and multiple regression (P = 0.04) to Δ UACR. When patients were divided according to Δ UACR in nonprogressors (Δ UACR < 0) and progressors (Δ UACR > 0), logistic regression showed that baseline GFR (OR = 1.04, CI95%: 1.00-1.09, P = 0.04) and plasma adiponectin (OR = 1.16, CI95%: 1.02-1.32, P = 0.02) were the only factors that predicted whether the patient would be a progressor or not.
Conclusion: In T2D patients, lower plasma adiponectin levels seem to be predictive of increased UACR.
التعليقات: Erratum in: Int Urol Nephrol. 2012 Aug;44(4):1159.
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المشرفين على المادة: 0 (Adiponectin)
AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20111014 Date Completed: 20121218 Latest Revision: 20220309
رمز التحديث: 20221213
DOI: 10.1007/s11255-011-0064-1
PMID: 21993769
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2584
DOI:10.1007/s11255-011-0064-1