دورية أكاديمية
Irradiation does not modify mechanical properties of cancellous bone under compression.
العنوان: | Irradiation does not modify mechanical properties of cancellous bone under compression. |
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المؤلفون: | Hernandez CJ; Sibley School of Mechanical and Aerospace Engineering and Department of Biomedical Engineering, Cornell University, 219 Upson Hall, Ithaca, NY 14853, USA. cjh275@cornell.edu, Ramsey DS, Dux SJ, Chu EH, Rimnac CM |
المصدر: | Clinical orthopaedics and related research [Clin Orthop Relat Res] 2012 Sep; Vol. 470 (9), pp. 2488-95. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0075674 Publication Model: Print Cited Medium: Internet ISSN: 1528-1132 (Electronic) Linking ISSN: 0009921X NLM ISO Abbreviation: Clin Orthop Relat Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2018- : [New York, NY] : Wolters Kluwer Original Publication: Philadelphia : Lippincott, |
مواضيع طبية MeSH: | Gamma Rays*/adverse effects, Femur/*radiation effects , Sterilization/*methods, Aged ; Aged, 80 and over ; Biomechanical Phenomena ; Bone Density ; Cadaver ; Elastic Modulus ; Female ; Femoral Fractures/etiology ; Femur/pathology ; Femur/transplantation ; Humans ; Microscopy, Fluorescence ; Middle Aged ; Porosity ; Stress, Mechanical ; Transplantation, Homologous ; Weight-Bearing |
مستخلص: | Background: Gamma radiation sterilization can make cortical bone allograft more brittle, but whether it influences mechanical properties and propensity to form microscopic cracks in structurally intact cancellous bone allograft is unknown. Questions/purposes: We therefore determined the effects of gamma radiation sterilization on structurally intact cancellous bone mechanical properties and damage formation in both low- and high-density femoral cancellous bone (volume fraction 9%-44%). Methods: We studied 26 cancellous bone cores from the proximal and distal femurs of 10 human female cadavers (49-82 years of age) submitted to a single compressive load beyond yield. Mechanical properties and the formation of microscopic cracks and other tissue damage (identified through fluorochrome staining) were compared between irradiated and control specimens. Results: We observed no alterations in mechanical properties with gamma radiation sterilization after taking into account variation in specimen porosity. No differences in microscopic tissue damage were observed between the groups. Conclusions: Although gamma radiation sterilization influences the mechanical properties and failure processes in cortical bone, it does not appear to influence the performance of cancellous bone under uniaxial loading. |
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معلومات مُعتمدة: | R01 AR057362 United States AR NIAMS NIH HHS; R01AR057362 United States AR NIAMS NIH HHS |
تواريخ الأحداث: | Date Created: 20111029 Date Completed: 20121025 Latest Revision: 20211020 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3830084 |
DOI: | 10.1007/s11999-011-2148-8 |
PMID: | 22033873 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1528-1132 |
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DOI: | 10.1007/s11999-011-2148-8 |