دورية أكاديمية
أعرض في EDS

Irradiation does not modify mechanical properties of cancellous bone under compression.

التفاصيل البيبلوغرافية
العنوان: Irradiation does not modify mechanical properties of cancellous bone under compression.
المؤلفون: Hernandez CJ; Sibley School of Mechanical and Aerospace Engineering and Department of Biomedical Engineering, Cornell University, 219 Upson Hall, Ithaca, NY 14853, USA. cjh275@cornell.edu, Ramsey DS, Dux SJ, Chu EH, Rimnac CM
المصدر: Clinical orthopaedics and related research [Clin Orthop Relat Res] 2012 Sep; Vol. 470 (9), pp. 2488-95.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0075674 Publication Model: Print Cited Medium: Internet ISSN: 1528-1132 (Electronic) Linking ISSN: 0009921X NLM ISO Abbreviation: Clin Orthop Relat Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : [New York, NY] : Wolters Kluwer
Original Publication: Philadelphia : Lippincott,
مواضيع طبية MeSH: Gamma Rays*/adverse effects, Femur/*radiation effects , Sterilization/*methods, Aged ; Aged, 80 and over ; Biomechanical Phenomena ; Bone Density ; Cadaver ; Elastic Modulus ; Female ; Femoral Fractures/etiology ; Femur/pathology ; Femur/transplantation ; Humans ; Microscopy, Fluorescence ; Middle Aged ; Porosity ; Stress, Mechanical ; Transplantation, Homologous ; Weight-Bearing
مستخلص: Background: Gamma radiation sterilization can make cortical bone allograft more brittle, but whether it influences mechanical properties and propensity to form microscopic cracks in structurally intact cancellous bone allograft is unknown.
Questions/purposes: We therefore determined the effects of gamma radiation sterilization on structurally intact cancellous bone mechanical properties and damage formation in both low- and high-density femoral cancellous bone (volume fraction 9%-44%).
Methods: We studied 26 cancellous bone cores from the proximal and distal femurs of 10 human female cadavers (49-82 years of age) submitted to a single compressive load beyond yield. Mechanical properties and the formation of microscopic cracks and other tissue damage (identified through fluorochrome staining) were compared between irradiated and control specimens.
Results: We observed no alterations in mechanical properties with gamma radiation sterilization after taking into account variation in specimen porosity. No differences in microscopic tissue damage were observed between the groups.
Conclusions: Although gamma radiation sterilization influences the mechanical properties and failure processes in cortical bone, it does not appear to influence the performance of cancellous bone under uniaxial loading.
References: Biomaterials. 2005 May;26(14):2033-42. (PMID: 15576177)
J Bone Joint Surg Br. 1996 May;78(3):363-8. (PMID: 8636167)
J Orthop Res. 2005 Sep;23(5):1054-8. (PMID: 16140190)
Cell Tissue Bank. 2011 Nov;12(4):281-8. (PMID: 20703816)
J Orthop Res. 1997 Jan;15(1):101-10. (PMID: 9066533)
Cell Tissue Bank. 2005;6(3):201-19. (PMID: 16151960)
J Orthop Res. 2001 Sep;19(5):927-34. (PMID: 11562143)
Bone. 2009 Apr;44(4):573-8. (PMID: 19110082)
J Bone Joint Surg Am. 1992 Jun;74(5):747-52. (PMID: 1624490)
Clin Orthop Relat Res. 1987 Dec;(225):7-16. (PMID: 3315383)
J Orthop Res. 1997 Jan;15(1):111-7. (PMID: 9066534)
J Biomech. 2003 Jul;36(7):897-904. (PMID: 12757797)
J Clin Epidemiol. 2007 Dec;60(12):1234-8. (PMID: 17998077)
Bone. 2007 May;40(5):1259-64. (PMID: 17329178)
J Biomech. 2004 Nov;37(11):1671-8. (PMID: 15388309)
J Orthop Res. 2000 May;18(3):426-31. (PMID: 10937629)
J Biomech. 2010 May 28;43(8):1509-13. (PMID: 20172526)
J Biomech. 1985;18(5):317-28. (PMID: 4008502)
Bone. 2006 Dec;39(6):1218-25. (PMID: 16904959)
J Biomech. 2001 May;34(5):569-77. (PMID: 11311697)
Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S267-73. (PMID: 9917646)
Clin Orthop Relat Res. 2008 Aug;466(8):1905-11. (PMID: 18509711)
Bone. 2005 Dec;37(6):825-32. (PMID: 16140600)
Neurosurgery. 2004 Jun;54(6):1405-11; discussion 1411-2. (PMID: 15157297)
J Bone Joint Surg Am. 2004 Dec;86(12):2648-57. (PMID: 15590849)
J Biomech Eng. 2002 Feb;124(1):63-71. (PMID: 11873773)
Cell Tissue Bank. 2008 Dec;9(4):289-98. (PMID: 18431690)
J Biomech. 2006;39(5):781-90. (PMID: 16488217)
Annu Rev Biomed Eng. 2001;3:307-33. (PMID: 11447066)
Biomaterials. 2004 May;25(11):2105-10. (PMID: 14741625)
معلومات مُعتمدة: R01 AR057362 United States AR NIAMS NIH HHS; R01AR057362 United States AR NIAMS NIH HHS
تواريخ الأحداث: Date Created: 20111029 Date Completed: 20121025 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3830084
DOI: 10.1007/s11999-011-2148-8
PMID: 22033873
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-1132
DOI:10.1007/s11999-011-2148-8