دورية أكاديمية
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
| العنوان: | A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. |
|---|---|
| المؤلفون: | Kulbe H; Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, Cancer Research UK, Bioinformatics and Biostatistics Service, London, United Kingdom., Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR |
| مؤلفون مشاركون: | Australian Ovarian Cancer Study Group |
| المصدر: | Cancer research [Cancer Res] 2012 Jan 01; Vol. 72 (1), pp. 66-75. Date of Electronic Publication: 2011 Nov 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Cytokines/*metabolism , Ovarian Neoplasms/*metabolism, Animals ; Biopsy ; Cell Line, Tumor ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; Mice ; Mice, Nude ; Ovarian Neoplasms/pathology ; Real-Time Polymerase Chain Reaction |
| مستخلص: | Constitutive production of inflammatory cytokines is a characteristic of many human malignant cell lines; however, the in vitro and in vivo interdependence of these cytokines, and their significance to the human cancer microenvironment, are both poorly understood. Here, we describe for the first time how three key cytokine/chemokine mediators of cancer-related inflammation, TNF, CXCL12, and interleukin 6, are involved in an autocrine cytokine network, the "TNF network," in human ovarian cancer. We show that this network has paracrine actions on angiogenesis, infiltration of myeloid cells, and NOTCH signaling in both murine xenografts and human ovarian tumor biopsies. Neutralizing antibodies or siRNA to individual members of this TNF network reduced angiogenesis, myeloid cell infiltration, and experimental peritoneal ovarian tumor growth. The dependency of network genes on TNF was shown by their downregulation in tumor cells from patients with advanced ovarian cancer following the infusion of anti-TNF antibodies. Together, the findings define a network of inflammatory cytokine interactions that are crucial to tumor growth and validate this network as a key therapeutic target in ovarian cancer. (©2011 AACR.) |
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| معلومات مُعتمدة: | 06-0433 United Kingdom AICR_ Worldwide Cancer Research; A10603 United Kingdom CRUK_ Cancer Research UK; G0501974(77044) United Kingdom MRC_ Medical Research Council; A6737 United Kingdom CRUK_ Cancer Research UK; G0501974 United Kingdom MRC_ Medical Research Council; G0601867 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Indexing Agency: NLM Local ID #: UKMS37683. |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20111109 Date Completed: 20120221 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3252703 |
| DOI: | 10.1158/0008-5472.CAN-11-2178 |
| PMID: | 22065722 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1538-7445 |
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| DOI: | 10.1158/0008-5472.CAN-11-2178 |