دورية أكاديمية
Modulation of Pseudomonas aeruginosa lipopolysaccharide-induced lung inflammation by chronic iron overload in rat.
| العنوان: | Modulation of Pseudomonas aeruginosa lipopolysaccharide-induced lung inflammation by chronic iron overload in rat. |
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| المؤلفون: | Lê BV; Peritox Laboratory EA4285-UMI 01, Faculty of Medicine, Picardy Jules Verne University, Amiens, France., Khorsi-Cauet H, Bach V, Gay-Quéheillard J |
| المصدر: | FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2012 Mar; Vol. 64 (2), pp. 255-64. Date of Electronic Publication: 2011 Nov 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: England NLM ID: 9315554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1574-695X (Electronic) Linking ISSN: 09288244 NLM ISO Abbreviation: FEMS Immunol Med Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2006- : Oxford : Blackwell Pub. Original Publication: Amsterdam ; New York : Published by Elsevier Science Publishers on behalf of the Federation of European Microbiological Societies, [1993- |
| مواضيع طبية MeSH: | Iron/*pharmacology , Iron Overload/*metabolism , Lipopolysaccharides/*pharmacology , Pneumonia/*metabolism, Analysis of Variance ; Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Capillary Permeability/drug effects ; Cytokines/analysis ; Cytokines/metabolism ; Ferric Compounds/administration & dosage ; Ferric Oxide, Saccharated ; Glucaric Acid/administration & dosage ; Iron Overload/immunology ; Lipopolysaccharides/immunology ; Lung/immunology ; Lung/metabolism ; Male ; Peroxidase/metabolism ; Pneumonia/chemically induced ; Pneumonia/immunology ; Pseudomonas aeruginosa/immunology ; Rats ; Rats, Wistar ; Weaning |
| مستخلص: | Iron constitutes a critical nutrient source for bacterial growth, so iron overload is a risk factor for bacterial infections. This study aimed at investigating the role of iron overload in modulating bacterial endotoxin-induced lung inflammation. Weaning male Wistar rats were intraperitoneally injected with saline or iron sucrose [15 mg kg(-1) body weight (bw), 3 times per week, 4 weeks]. They were then intratracheally injected with Pseudomonas aeruginosa lipopolysaccharide (LPS) (5 μg kg(-1) bw) or saline. Inflammatory indices were evaluated 4 or 18 h post-LPS/saline injection. At 4 h, LPS-treated groups revealed significant increases in the majority of inflammatory parameters (LPS-binding protein (LBP), immune cell recruitment, inflammatory cytokine synthesis, myeloperoxidase activity, and alteration of alveolar-capillary permeability), as compared with control groups. At 18 h, these parameters reduced strongly with the exception for LBP content and interleukin (IL)-10. In parallel, iron acted as a modulator of immune cell recruitment; LBP, tumor necrosis factor-α, cytokine-induced neutrophil chemoattractant 3, and IL-10 synthesis; and alveolar-capillary permeability. Therefore, P. aeruginosa LPS may only act as an acute lung inflammatory molecule, and iron overload may modulate lung inflammation by enhancing different inflammatory parameters. Thus, therapy for iron overload may be a novel and efficacious approach for the prevention and treatment of bacterial lung inflammations. (© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Cytokines) 0 (Ferric Compounds) 0 (Lipopolysaccharides) E1UOL152H7 (Iron) EC 1.11.1.7 (Peroxidase) FZ7NYF5N8L (Ferric Oxide, Saccharated) QLZ991V4A2 (Glucaric Acid) |
| تواريخ الأحداث: | Date Created: 20111110 Date Completed: 20120919 Latest Revision: 20181201 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1574-695X.2011.00897.x |
| PMID: | 22066700 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1574-695X |
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| DOI: | 10.1111/j.1574-695X.2011.00897.x |