دورية أكاديمية
Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease.
| العنوان: | Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease. |
|---|---|
| المؤلفون: | Truc P; Institut de Recherche pour le Développement, Unité Mixte de Recherche 177 IRD-CIRAD, Campus International de Baillarguet, TA A17/G, 34398, Montpellier Cedex 5, France. Philippe.Truc@ird.fr, Lando A, Penchenier L, Vatunga G, Josenando T |
| المصدر: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2012 Jan; Vol. 106 (1), pp. 10-4. Date of Electronic Publication: 2011 Nov 16. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| مواضيع طبية MeSH: | Polymerase Chain Reaction*, Eflornithine/*therapeutic use , Pentamidine/*therapeutic use , Trypanocidal Agents/*therapeutic use , Trypanosoma brucei gambiense/*isolation & purification , Trypanosomiasis, African/*diagnosis, Adult ; Angola/epidemiology ; Animals ; Female ; Follow-Up Studies ; Humans ; Lymphocyte Count ; Male ; Nucleic Acid Amplification Techniques ; Recurrence ; Remission Induction ; Trypanosoma brucei gambiense/genetics ; Trypanosomiasis, African/cerebrospinal fluid ; Trypanosomiasis, African/epidemiology |
| مستخلص: | Biological and clinical observations are described for 224 patients infected by human African trypanosomiasis (HAT) in Angola in 2007 and 2008. Seven patients were initially classified in stage 1 (S1), 17 intermediate stage (IS) (WBC <20 lymphocytes/μl with absence of trypanosomes in cerebrospinal fluid (CSF) and no neurological signs), and 200 in stage 2 (S2). Out of 224 patients, 165 (73.6%) presented one or more neurological signs. During treatment with eflornithine, six deaths of S2 patients occurred, five of which were because of an encephalopathy syndrome. Nine patients were diagnosed with a relapse or suspected treatment failure during the follow-up: eight patients after treatment with eflornithine (relapse rate 4.1%) and one patient after pentamidine (6.6%). The contribution of PCR for stage determination evaluated for S1 and IS confirms the difficulty of stage determination, as one S1 patient and two IS patients were carriers of trypanosomes detected a posteriori by PCR in CSF but were treated with pentamidine while follow-up did not confirm treatment efficacy. Since 2001 in Angola, either by passive or active mode detection, approximately 80% of the new cases every year were in S2, whereas the annual number of cases has regressed, probably because the transmission of HAT is decreasing. However, stage determination and treatment remain two major issues for the chronic form of sleeping sickness. (Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Trypanocidal Agents) 673LC5J4LQ (Pentamidine) ZQN1G5V6SR (Eflornithine) |
| تواريخ الأحداث: | Date Created: 20111119 Date Completed: 20120206 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.trstmh.2011.10.002 |
| PMID: | 22093811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-3503 |
|---|---|
| DOI: | 10.1016/j.trstmh.2011.10.002 |