دورية أكاديمية
أعرض في EDS

Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection.

التفاصيل البيبلوغرافية
العنوان: Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection.
المؤلفون: Behura SK; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA., Gomez-Machorro C, Harker BW, deBruyn B, Lovin DD, Hemme RR, Mori A, Romero-Severson J, Severson DW
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Nov; Vol. 5 (11), pp. e1385. Date of Electronic Publication: 2011 Nov 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Aedes/*genetics , Aedes/*virology , Dengue Virus/*physiology , Insect Vectors/*genetics , Insect Vectors/*virology, Aedes/metabolism ; Animals ; Cluster Analysis ; Dengue/transmission ; Dengue/virology ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Genes, Insect ; Host-Pathogen Interactions ; Humans ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Insect Vectors/metabolism ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Signal Transduction
مستخلص: Background: The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide. The early time periods after infection with DENV define critical cellular processes that determine ultimate success or failure of the virus to establish infection in the mosquito.
Methods and Results: To identify genes involved in these processes, we performed genome-wide transcriptome profiling between susceptible and refractory A. aegypti strains at two critical early periods after challenging them with DENV. Genes that responded coordinately to DENV infection in the susceptible strain were largely clustered in one specific expression module, whereas in the refractory strain they were distributed in four distinct modules. The susceptible response module in the global transcriptional network showed significant biased representation with genes related to energy metabolism and DNA replication, whereas the refractory response modules showed biased representation across different metabolism pathway genes including cytochrome P450 and DDT [1,1,1-Trichloro-2,2-bis(4-chlorophenyl) ethane] degradation genes, and genes associated with cell growth and death. A common core set of coordinately expressed genes was observed in both the susceptible and refractory mosquitoes and included genes related to the Wnt (Wnt: wingless [wg] and integration 1 [int1] pathway), MAPK (Mitogen-activated protein kinase), mTOR (mammalian target of rapamycin) and JAK-STAT (Janus Kinase - Signal Transducer and Activator of Transcription) pathways.
Conclusions: Our data revealed extensive transcriptional networks of mosquito genes that are expressed in modular manners in response to DENV infection, and indicated that successfully defending against viral infection requires more elaborate gene networks than hosting the virus. These likely play important roles in the global-cross talk among the mosquito host factors during the critical early DENV infection periods that trigger the appropriate host action in susceptible vs. refractory mosquitoes.
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معلومات مُعتمدة: R01 AI059342 United States AI NIAID NIH HHS; R01-AI059342 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Insect Proteins)
تواريخ الأحداث: Date Created: 20111122 Date Completed: 20120319 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3216916
DOI: 10.1371/journal.pntd.0001385
PMID: 22102922
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0001385