دورية أكاديمية
أعرض في EDS

Is the fibronectin-aggrecan complex present in cervical disk disease?

التفاصيل البيبلوغرافية
العنوان: Is the fibronectin-aggrecan complex present in cervical disk disease?
المؤلفون: Gajendran VK; Department of Orthopaedic Surgery, Stanford University, Redwood City, CA, USA. varun182@stanford.edu, Reuter MW, Golish SR, Hanna LS, Scuderi GJ
المصدر: PM & R : the journal of injury, function, and rehabilitation [PM R] 2011 Nov; Vol. 3 (11), pp. 1030-4.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101491319 Publication Model: Print Cited Medium: Internet ISSN: 1934-1563 (Electronic) Linking ISSN: 19341482 NLM ISO Abbreviation: PM R Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : [Hoboken, NJ] : Wiley
Original Publication: New York, NY : Elsevier
مواضيع طبية MeSH: Aggrecans/*metabolism , Cervical Vertebrae/*chemistry , Fibronectins/*metabolism , Intervertebral Disc Degeneration/*metabolism , Intervertebral Disc Displacement/*metabolism, Adult ; Aged ; Biomarkers/metabolism ; Cervical Vertebrae/pathology ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc Degeneration/diagnosis ; Intervertebral Disc Displacement/diagnosis ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index
مستخلص: Objective: To investigate the presence of inflammatory cytokines and the fibronectin-aggrecan complex (FAC) in persons undergoing surgical treatment for cervical radiculopathy caused by disk herniation.
Design: Single-center, prospective, consecutive case series.
Setting: A single large academic institution.
Patients: A total of 11 patients with radiculopathic pain and magnetic resonance imaging findings positive for disk herniation elected to undergo single-level cervical diskectomy. METHODS OR INTERVENTIONS: Lavage was performed by needle injection and aspiration upon entering the disk space for fluoroscopic localization before diskectomy.
Main Outcome Measurements: The lavage fluid was assayed for pH and the FAC, as well as for the cytokines interleukin-6 (IL-6), interferon-γ, monocyte chemotactic protein (MCP), and macrophage inhibitory protein-1β.
Results: The subjects were 7 women and 4 men with a mean age of 50.6 years (SE 9.7; range, 36-70 years). The mean concentrations (SE; range) in picograms per milliliter were 7.9 (4.4; 0-44) for IL-6, 25.3 (15.5; 0-159) for interferon-γ, 16.1 (11.9; 0-121) for MCP, and 6.1 (2.8; 0-29) for macrophage inhibitory protein-1β. The optical density of the FAC at 450 nm was 0.151 (0.036; 0.1-0.32), and the pH was 6.68 (0.1; 6.10-7.15). Statistically significant correlations were found between MCP and FAC (P = .036) and between FAC and pH (P = .008).
Conclusions: Biochemical analysis of injured cervical intervertebral disks reveals the presence of inflammatory markers such as MCP, fragments of structural matrix proteins such as FAC, and a correlation with pH. Further evaluation of the FAC as a potential diagnostic biomarker or therapeutic target is warranted in the cervical spine.
(Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Aggrecans)
0 (Biomarkers)
0 (Fibronectins)
SCR Disease Name: Intervertebral disc disease
تواريخ الأحداث: Date Created: 20111124 Date Completed: 20120403 Latest Revision: 20151119
رمز التحديث: 20240628
DOI: 10.1016/j.pmrj.2011.07.003
PMID: 22108230
قاعدة البيانات: MEDLINE
الوصف
تدمد:1934-1563
DOI:10.1016/j.pmrj.2011.07.003