دورية أكاديمية
HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
| العنوان: | HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate. |
|---|---|
| المؤلفون: | Abdel-Moneim AS; College of Medicine, Taif University, Al-Taif, Saudi Arabia. asa@tu.edu.sa, Bamaga MS, Shehab GM, Abu-Elsaad AA, Farahat FM |
| المصدر: | PloS one [PLoS One] 2012; Vol. 7 (1), pp. e29781. Date of Electronic Publication: 2012 Jan 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Hepacivirus/*genetics , Hepatitis C/*epidemiology , Hepatitis C/*virology, 5' Untranslated Regions/genetics ; Adolescent ; Adult ; Aged ; Antibodies, Viral/immunology ; Base Sequence ; Female ; Genotype ; Hepacivirus/immunology ; Hepatitis C/genetics ; Hepatitis C/immunology ; Humans ; Immunoassay ; Luminescent Measurements ; Male ; Middle Aged ; Molecular Sequence Data ; Phylogeny ; Prevalence ; Saudi Arabia/epidemiology ; Seroepidemiologic Studies ; Young Adult |
| مستخلص: | HCV is a major etiological agent of liver disease with a high rate of chronic evolution. The virus possesses 6 genotypes with many subtypes. The rate of spontaneous clearance among HCV infected individuals denotes a genetic determinant factor. The current study was designed in order to estimate the rate of HCV infection and ratio of virus clearance among a group of infected patients in Saudi Arabia from 2008 to 2011. It was additionally designed to determine the genotypes of the HCV in persistently infected patients. HCV seroprevalence was conducted on a total of 15,323 individuals. Seropositive individuals were tested by Cobas AmpliPrep/Cobas TaqMan HCV assay to determine the ratio of persistently infected patients to those who showed spontaneous viral clearance. HCV genotyping on random samples from persistently infected patients were conducted based on the differences in the 5'untranslated region (5'UTR). Anti-HCV antibodies were detected in 7.3% of the totally examined sera. A high percentage of the HCV infected individuals experienced virus clearance (48.4%). HCV genotyping revealed the presence of genotypes 1 and 4, the latter represented 97.6% of the tested strains. Evidences of the widespread of the HCV genotype 4 and a high rate of HCV virus clearance were found in Saudi Arabia. |
| References: | J Hepatol. 2011 Jun;54(6):1250-62. (PMID: 21316497) J Clin Microbiol. 2007 Apr;45(4):1102-12. (PMID: 17287328) J Clin Microbiol. 1999 Aug;37(8):2625-30. (PMID: 10405412) J Gastroenterol Hepatol. 2000 Sep;15(9):1054-8. (PMID: 11059937) Nature. 2009 Oct 8;461(7265):798-801. (PMID: 19759533) J Virol. 2006 Sep;80(18):9144-50. (PMID: 16940525) N Engl J Med. 1990 Oct 18;323(16):1107-12. (PMID: 2170839) J Hepatol. 1995 Dec;23(6):654-61. (PMID: 8750163) Immunity. 1999 Apr;10(4):439-49. (PMID: 10229187) J Clin Microbiol. 2008 Jun;46(6):1901-6. (PMID: 18400913) J Med Virol. 2003 Nov;71(3):391-8. (PMID: 12966544) N Engl J Med. 1999 Sep 16;341(12):866-70. (PMID: 10498458) Intervirology. 1994;37(2):108-13. (PMID: 7529218) Gut. 2006 Aug;55(8):1183-7. (PMID: 16434426) Ann Intern Med. 2000 Jan 18;132(2):105-11. (PMID: 10644270) Nature. 2009 Sep 17;461(7262):399-401. (PMID: 19684573) Lancet. 1990 Mar 10;335(8689):558-60. (PMID: 1968574) Methods Mol Biol. 2009;510:33-53. (PMID: 19009252) Clin Diagn Lab Immunol. 2003 Nov;10(6):1159-60. (PMID: 14607885) N Engl J Med. 1992 Dec 31;327(27):1906-11. (PMID: 1454085) J Viral Hepat. 1995;2(6):293-6. (PMID: 8732175) N Engl J Med. 1999 Apr 22;340(16):1228-33. (PMID: 10210705) J Infect Dev Ctries. 2009 Apr 30;3(3):235-8. (PMID: 19759481) N Engl J Med. 1992 Dec 31;327(27):1899-905. (PMID: 1280771) Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3392-6. (PMID: 1849654) Hepatology. 1994 May;19(5):1321-4. (PMID: 8175159) Am J Med. 1999 Dec 27;107(6B):10S-15S. (PMID: 10653449) Saudi Med J. 2006 Jun;27(6):781-7. (PMID: 16758035) Transfusion. 1994 Feb;34(2):135-7. (PMID: 8310483) Hepatology. 2000 Oct;32(4 Pt 1):818-23. (PMID: 11003628) JAMA. 1989 Sep 1;262(9):1201-5. (PMID: 2503630) J Clin Microbiol. 2006 Mar;44(3):729-37. (PMID: 16517847) Ann Saudi Med. 2000 Sep-Nov;20(5-6):394-7. (PMID: 17264630) BMJ. 2002 Feb 23;324(7335):450-3. (PMID: 11859045) Nat Rev Immunol. 2005 Mar;5(3):215-29. (PMID: 15738952) Bioinformatics. 2001 Dec;17(12):1244-5. (PMID: 11751241) Hemodial Int. 2007 Jul;11(3):354-67. (PMID: 17576302) N Engl J Med. 1999 Aug 19;341(8):556-62. (PMID: 10451460) |
| سلسلة جزيئية: | GENBANK JN808433; JN808434; JN808435; JN808436; JN808437; JN808438; JN808439; JN808440; JN808441; JN808442 |
| المشرفين على المادة: | 0 (5' Untranslated Regions) 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20120119 Date Completed: 20120529 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3258249 |
| DOI: | 10.1371/journal.pone.0029781 |
| PMID: | 22253780 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!