دورية أكاديمية
Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation.
| العنوان: | Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation. |
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| المؤلفون: | Fragopoulou AF; Department of Cell Biology and Biophysics, Athens University, Athens, Greece. madofrag@biol.uoa.gr, Samara A, Antonelou MH, Xanthopoulou A, Papadopoulou A, Vougas K, Koutsogiannopoulou E, Anastasiadou E, Stravopodis DJ, Tsangaris GT, Margaritis LH |
| المصدر: | Electromagnetic biology and medicine [Electromagn Biol Med] 2012 Dec; Vol. 31 (4), pp. 250-74. Date of Electronic Publication: 2012 Jan 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101133002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-8386 (Electronic) Linking ISSN: 15368386 NLM ISO Abbreviation: Electromagn Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Monticello, NY : Marcel Dekker, Inc., c2002- |
| مواضيع طبية MeSH: | Brain/*metabolism , Brain/*radiation effects , Cell Phone/*instrumentation , Proteome/*metabolism , Proteome/*radiation effects , Whole-Body Irradiation/*adverse effects , Whole-Body Irradiation/*instrumentation , Wireless Technology/*instrumentation, Animals ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Transcriptome/radiation effects |
| مستخلص: | The objective of this study was to investigate the effects of two sources of electromagnetic fields (EMFs) on the proteome of cerebellum, hippocampus, and frontal lobe in Balb/c mice following long-term whole body irradiation. Three equally divided groups of animals (6 animals/group) were used; the first group was exposed to a typical mobile phone, at a SAR level range of 0.17-0.37 W/kg for 3 h daily for 8 months, the second group was exposed to a wireless DECT base (Digital Enhanced Cordless Telecommunications/Telephone) at a SAR level range of 0.012-0.028 W/kg for 8 h/day also for 8 months and the third group comprised the sham-exposed animals. Comparative proteomics analysis revealed that long-term irradiation from both EMF sources altered significantly (p < 0.05) the expression of 143 proteins in total (as low as 0.003 fold downregulation up to 114 fold overexpression). Several neural function related proteins (i.e., Glial Fibrillary Acidic Protein (GFAP), Alpha-synuclein, Glia Maturation Factor beta (GMF), and apolipoprotein E (apoE)), heat shock proteins, and cytoskeletal proteins (i.e., Neurofilaments and tropomodulin) are included in this list as well as proteins of the brain metabolism (i.e., Aspartate aminotransferase, Glutamate dehydrogenase) to nearly all brain regions studied. Western blot analysis on selected proteins confirmed the proteomics data. The observed protein expression changes may be related to brain plasticity alterations, indicative of oxidative stress in the nervous system or involved in apoptosis and might potentially explain human health hazards reported so far, such as headaches, sleep disturbance, fatigue, memory deficits, and brain tumor long-term induction under similar exposure conditions. |
| المشرفين على المادة: | 0 (Proteome) |
| تواريخ الأحداث: | Date Created: 20120124 Date Completed: 20130417 Latest Revision: 20220311 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3109/15368378.2011.631068 |
| PMID: | 22263702 |
| قاعدة البيانات: | MEDLINE |
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