دورية أكاديمية
Loss of HLA class I and mismatch repair protein expression in sporadic endometrioid endometrial carcinomas.
| العنوان: | Loss of HLA class I and mismatch repair protein expression in sporadic endometrioid endometrial carcinomas. |
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| المؤلفون: | de Jong RA; Department of Gynecologic Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Boerma A, Boezen HM, Mourits MJ, Hollema H, Nijman HW |
| المصدر: | International journal of cancer [Int J Cancer] 2012 Oct 15; Vol. 131 (8), pp. 1828-36. Date of Electronic Publication: 2012 Mar 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| مواضيع طبية MeSH: | Genes, MHC Class I*, Adaptor Proteins, Signal Transducing/*metabolism , Biomarkers, Tumor/*metabolism , DNA-Binding Proteins/*metabolism , Endometrial Neoplasms/*metabolism , MutS Homolog 2 Protein/*metabolism , Nuclear Proteins/*metabolism, Aged ; CD8-Positive T-Lymphocytes/metabolism ; Endometrial Neoplasms/immunology ; Endometrial Neoplasms/mortality ; Female ; Humans ; Immunoenzyme Techniques ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; MutL Protein Homolog 1 ; Neoplasm Grading ; Prognosis ; Survival Rate |
| مستخلص: | Tumor cells can escape from cytotoxic T-cell responses by downregulation of human leukocyte antigen (HLA) class I molecules expressed at the cell surface which has been associated with a deficient mismatch repair (MMR) system in colorectal carcinomas. Our study investigated the association between expression of MMR proteins and HLA class I in sporadic endometrioid endometrial carcinomas (EC). In a consecutively selected cohort of 486 EC patients, MMR proteins (MLH1, MSH2 and MSH6) and HLA class I (HLA-A, -B, -C or β(2) m) were investigated by immunohistochemistry. Expression levels of MMR proteins and HLA class I were compared between low-grade and high-grade ECs. HLA class I expression was compared between tumors with loss (negative immunostaining of ≥1 MMR protein) and expression of MMR proteins. Associations between previously determined numbers of intratumoral CD8(+) T-lymphocytes and expression of MMR proteins and HLA class I and the influence on survival was determined. ECs with loss of MMR protein expression (33.5%) more frequently have loss of HLA-B/C (37.3%), compared to ECs with MMR protein expression (25.5%, p = 0.007). Patients with loss of MMR proteins have a worse disease-specific survival compared to patients with expression (p = 0.039). CD8(+) T-lymphocytes have a positive influence on disease-free and disease-specific survival in the total EC cohort but not in patients with loss of MMR protein expression. In conclusion, our results indicate that loss of MMR protein expression is related to selective downregulation of HLA class I which contributes to immune escape in EC with an abnormal MMR system. (Copyright © 2012 UICC.) |
| المشرفين على المادة: | 0 (Adaptor Proteins, Signal Transducing) 0 (Biomarkers, Tumor) 0 (DNA-Binding Proteins) 0 (G-T mismatch-binding protein) 0 (MLH1 protein, human) 0 (Nuclear Proteins) EC 3.6.1.3 (MSH2 protein, human) EC 3.6.1.3 (MutL Protein Homolog 1) EC 3.6.1.3 (MutS Homolog 2 Protein) |
| تواريخ الأحداث: | Date Created: 20120131 Date Completed: 20121031 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ijc.27449 |
| PMID: | 22287095 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0215 |
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| DOI: | 10.1002/ijc.27449 |