دورية أكاديمية
أعرض في EDS

Trends in maintenance immunosuppressive drugs used in taiwanese kidney transplant recipients: an analysis of the national health insurance research database.

التفاصيل البيبلوغرافية
العنوان: Trends in maintenance immunosuppressive drugs used in taiwanese kidney transplant recipients: an analysis of the national health insurance research database.
المؤلفون: Tsai SF; Division of Nephrology and Division of General Medicine, Taichung Veterans General Hospital, Taiwan., Cheng CY, Shu KH, Wu MJ
المصدر: Transplantation proceedings [Transplant Proc] 2012 Jan; Vol. 44 (1), pp. 190-2.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, N.Y. : Elsevier Science Inc.
Original Publication: New York Stratton.
مواضيع طبية MeSH: Kidney Transplantation*/immunology, Graft Rejection/*prevention & control , Immunosuppression Therapy/*trends , Immunosuppressive Agents/*therapeutic use , Practice Patterns, Physicians'/*trends, Azathioprine/therapeutic use ; Cyclosporine/therapeutic use ; Databases as Topic ; Drug Therapy, Combination ; Drug Utilization/trends ; Graft Rejection/immunology ; Graft Survival/drug effects ; Humans ; Immunosuppression Therapy/adverse effects ; Immunosuppressive Agents/adverse effects ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; National Health Programs/trends ; Sirolimus/therapeutic use ; Tacrolimus/therapeutic use ; Taiwan ; Time Factors ; Treatment Outcome
مستخلص: Trends in maintenance immunosuppressive drugs used among Taiwanese kidney transplant recipients have not been reported before. We examined the National Health Insurance Research Database to analyze trends in maintenance immunosuppressive drugs used in Taiwanese kidney transplant recipients for the years 2002-2009. The new case number of kidney transplant recipients ranged from 302 to 673 per year. In 2009, 5276 kidney transplant recipients received immunosuppressive therapy. The 5-year renal graft survival rate of kidney transplant recipients was 93%. In 2009, the most common immunosuppressive therapy among Taiwanese kidney transplant recipients was a triple regimen that included tacrolimus, mycophenolate mofetil, and corticosteroid. There was a significant increase in the use of a tacrolimus-based regimen from 35.1%-58.2%, while the use of cyclosporine decreased from 62.2%-24.8% (P < .05). The percentage of calcineurin inhibitor-free regimen increased from 2.7%-17%. Moreover, the use of Rapamune dramatically increased from 8.2%-22.6% in 2002-2004. However, the percentage of kidney transplant recipients using Rapamune maintained 23 ± 1.6% in 2004-2009. The use of mycophenolic acid remained stable at about 74.9 ± 3.2% in 2002-2009. As predicted, the use of Imuran decreased from 6.9%-3.5%. In summary, although calcineurin inhibitors remained the mainstay of immunosuppressive drugs, these findings suggest a general trends toward individualized regimens and the use of calcineurin inhibitor-free and mammalian target of rapamycin inhibitors-based regimens in Taiwanese kidney transplant recipients.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Immunosuppressive Agents)
83HN0GTJ6D (Cyclosporine)
HU9DX48N0T (Mycophenolic Acid)
MRK240IY2L (Azathioprine)
W36ZG6FT64 (Sirolimus)
WM0HAQ4WNM (Tacrolimus)
تواريخ الأحداث: Date Created: 20120208 Date Completed: 20120524 Latest Revision: 20211203
رمز التحديث: 20221213
DOI: 10.1016/j.transproceed.2011.12.018
PMID: 22310612
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2623
DOI:10.1016/j.transproceed.2011.12.018