دورية أكاديمية
أعرض في EDS

TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.

التفاصيل البيبلوغرافية
العنوان: TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia.
المؤلفون: Pérez C; Laboratory of Myeloproliferative Syndromes, Oncology Area, University of Navarra, Pamplona, Spain., Martínez-Calle N, Martín-Subero JI, Segura V, Delabesse E, Fernandez-Mercado M, Garate L, Alvarez S, Rifon J, Varea S, Boultwood J, Wainscoat JS, Cruz Cigudosa J, Calasanz MJ, Cross NC, Prósper F, Agirre X
المصدر: PloS one [PLoS One] 2012; Vol. 7 (2), pp. e31605. Date of Electronic Publication: 2012 Feb 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: DNA-Binding Proteins/*genetics , Leukemia, Myelomonocytic, Chronic/*genetics , Proto-Oncogene Proteins/*genetics, 5-Methylcytosine ; Computational Biology ; Cytosine/analogs & derivatives ; DNA Methylation/genetics ; Dioxygenases ; Enhancer of Zeste Homolog 2 Protein ; Humans ; Isocitrate Dehydrogenase/genetics ; Janus Kinase 2/genetics ; Mutation ; Oligonucleotide Array Sequence Analysis ; Polycomb Repressive Complex 2 ; Transcription Factors/genetics
مستخلص: Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes such as TET2 or EZH2 that are implicated in epigenetic mechanisms. We have performed genome-wide DNA methylation arrays and mutational analysis of TET2, IDH1, IDH2, EZH2 and JAK2 in a group of 24 patients with CMML. 249 genes were differentially methylated between CMML patients and controls. Using Ingenuity pathway analysis, we identified enrichment in a gene network centered around PLC, JNK and ERK suggesting that these pathways, whose deregulation has been recently described in CMML, are affected by epigenetic mechanisms. Mutations of TET2, JAK2 and EZH2 were found in 15 patients (65%), 4 patients (17%) and 1 patient (4%) respectively while no mutations in the IDH1 and IDH2 genes were identified. Interestingly, patients with wild type TET2 clustered separately from patients with TET2 mutations, showed a higher degree of hypermethylation and were associated with higher risk karyotypes. Our results demonstrate the presence of aberrant DNA methylation in CMML and identifies TET2 mutant CMML as a biologically distinct disease subtype with a different epigenetic profile.
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المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (Proto-Oncogene Proteins)
0 (Transcription Factors)
1123-95-1 (5-hydroxymethylcytosine)
6R795CQT4H (5-Methylcytosine)
8J337D1HZY (Cytosine)
EC 1.1.1.41 (IDH2 protein, human)
EC 1.1.1.41 (Isocitrate Dehydrogenase)
EC 1.1.1.42. (IDH1 protein, human)
EC 1.13.11.- (Dioxygenases)
EC 1.13.11.- (TET2 protein, human)
EC 2.1.1.43 (EZH2 protein, human)
EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein)
EC 2.1.1.43 (Polycomb Repressive Complex 2)
EC 2.7.10.2 (JAK2 protein, human)
EC 2.7.10.2 (Janus Kinase 2)
تواريخ الأحداث: Date Created: 20120214 Date Completed: 20120611 Latest Revision: 20220812
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3273467
DOI: 10.1371/journal.pone.0031605
PMID: 22328940
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0031605