دورية أكاديمية
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Changes in anterior segment morphology after laser peripheral iridotomy: an anterior segment optical coherence tomography study.

التفاصيل البيبلوغرافية
العنوان: Changes in anterior segment morphology after laser peripheral iridotomy: an anterior segment optical coherence tomography study.
المؤلفون: How AC; Singapore Eye Research Institute and Singapore National Eye Center, Singapore., Baskaran M, Kumar RS, He M, Foster PJ, Lavanya R, Wong HT, Chew PT, Friedman DS, Aung T
المصدر: Ophthalmology [Ophthalmology] 2012 Jul; Vol. 119 (7), pp. 1383-7. Date of Electronic Publication: 2012 Mar 10.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7802443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-4713 (Electronic) Linking ISSN: 01616420 NLM ISO Abbreviation: Ophthalmology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : New York : Elsevier
Original Publication: Rochester, Minn., American Academy of Ophthalmology.
مواضيع طبية MeSH: Iridectomy* , Laser Therapy* , Tomography, Optical Coherence*, Anterior Eye Segment/*pathology , Glaucoma, Angle-Closure/*prevention & control, Female ; Glaucoma, Angle-Closure/physiopathology ; Gonioscopy ; Humans ; Intraocular Pressure/physiology ; Iris/surgery ; Lasers, Solid-State/therapeutic use ; Male ; Middle Aged ; Prospective Studies ; Visual Acuity/physiology ; Visual Fields/physiology
مستخلص: Purpose: Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate changes in these parameters after laser peripheral iridotomy (LPI) in a cohort of primary angle-closure suspects (PACS).
Design: Prospective observational study.
Participants and Controls: A total of 176 PACS aged ≥ 50 years who underwent LPI in 1 eye.
Methods: We analyzed ASOCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from all subjects using customized software before and 1 week after LPI. Multivariate linear regression analysis was performed for predictors of percentage change in mean angle opening distance (AOD750).
Main Outcome Measures: Change in ASOCT parameters after LPI.
Results: The mean age of participants was 63 ± 7.3 years. The majority of subjects were Chinese (95.5%) and women (76.7%). Mean angle width (modified Shaffer grade) changed from 0.68 ± 0.54 at baseline to 1.76±0.69 after LPI (P<0.001) with a corresponding increase in mean AOD500 (0.12 vs. 0.19 mm, P<0.001), trabecular iris surface area (TISA500, 0.06 vs. 0.08 mm(2), P<0.001), and angle recess area (ARA, 0.13 vs. 0.17 mm(2), P<0.001). Mean ACA (15.0 vs. 16.0 mm(2), P<0.001) and ACV (91.6 vs. 103.0 mm(3), P<0.001) increased significantly after LPI, but there was no change in ACW, anterior chamber depth (ACD), or LV. Mean I-curv was reduced (0.375 vs. 0.18 mm, P<0.001) after LPI, but there was no significant change in IT or I-area. After multivariate analysis, mean LV (β = 0.286, P = 0.001), mean IT at 2000 μm (IT2000, β = 0.172, P = 0.034), and intraocular pressure (β = 0.159, P = 0.042) at baseline were found to be associated with ΔAOD750.
Conclusions: This study confirms that LPI results in a significant increase in the angle width in PACS. The ACA and ACV increased after LPI, but there was no change in ACD, ACW, LV, IT, or I-area. The increase in ACA/ACV was mainly due to decreased I-curv after LPI.
(Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
تواريخ الأحداث: Date Created: 20120314 Date Completed: 20121003 Latest Revision: 20220310
رمز التحديث: 20231215
DOI: 10.1016/j.ophtha.2012.01.019
PMID: 22410350
قاعدة البيانات: MEDLINE
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